NYU Langone’s Laura and Isaac Perlmutter Cancer Center

Sugar-rich foods exacerbate antibiotic-induced microbiome disruption

Diet shapes the composition of the gut microbiota1; however, the specific effects of distinct food groups on microbiome dynamics are unclear, particularly in circumstances of extreme perturbation. Here we evaluated the relationship between diet and intestinal microbiome dynamics...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Spatial mixed models for assessing environmental exposure effects on the microbiome

Environmental exposures such as air pollution may influence human health partly through microbiome, but statistical modeling is challenged by spatial dependence across regions and ecological correlations among taxa. We propose SpaMixed, a novel spatial mixed modeling framework fo...

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

Abstract DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...