Novosibirsk State University

Randomization of the Damaged Base-Capping Loop Rewires Substrate Specificity in Formamidopyrimidine–DNA Glycosylase

Abstract Formamidopyrimidine–DNA glycosylase (Fpg) is a bacterial base excision repair enzyme that removes 8-oxoguanine (8-oxoG) and some other oxidatively damaged nucleobases from DNA. Fpg hydrolyzes the N-glycosidic bond of the damaged nucleotide and nicks DNA at the resulting...

Karyotypes and sex chromosome diversity in three stonefly species (Plecoptera: Perlodidae, Perlidae) from Siberia

The current paper focuses on studying morphology of the autosomes and sex chromosomes in karyotypes of three stonefly species from Siberia. We provide new cytogenetic data for species from Perlodidae (Arcynopteryx dichroa (McLachlan, 1872), Megarcys ochracea (Klapálek, 1912)) and...

A Curated Phenotype-Linked HIV-1 Sequence Dataset for Machine Learning Approaches to Tropism Prediction, Disease Progression and Proviral Reservoir Studies

HIV-1 tropism toward the CCR5 and CXCR4 coreceptors is an important viral characteristic associated with cell entry, the potential use of specific entry inhibitors, studies of disease progression, and analyses of proviral reservoirs. The development of tools for genotypic tropism...

From Solution Associates to Crystal Packing: Molecular Origins of Solvent-Dependent Polymorphism in Tecovirimat

Abstract Solvent-dependent polymorphism remains one of the central challenges in pharmaceutical crystallization. The molecular mechanisms governing polymorph selection are often poorly understood. In the present work, molecular dynamics (MD) simulations were used to investigate t...

On Recognition of Simple Groups with Disconnected Prime Graph by Spectrum

Abstract Finite groups are said to be isospectral if the sets of orders of their elements coincide. This paper completes the description of finite groups that are isospectral to finite simple groups with disconnected prime graphs.

Generating the symmetric group by three prefix reversals

The cubic pancake graphs are Cayley graphs over the symmetric group $\mathrm{Sym}_n$ generated by three prefix reversals. There is the following open problem: characterize all the sets of three prefix reversals that generate $\mathrm{Sym}_n$. As the largest prefix reversal of len...

Features of the Synthesis and Electronic Structure of LiIr

Abstract The partial density of states for LiIr with and without spin–orbit coupling was calculated using the DFT method. It was found that the iridium d-orbitals make the main contribution to the density of states. LiIr intermetallic compound has metal-like properties, and elect...

Paired neuronal-haemodynamic neurovascular coupling measures and cognitive performance in vascular pathology: protocol for a systematic review and meta-analysis

Abstract Background Neurovascular coupling (NVC) links neuronal activity to haemodynamic responses. Altered NVC may contribute to cognitive impairment in vascular pathology, but evidence is limited by inconsistent definitions and by the conflation of paired neuronal–haemodynamic...

Bubbles, dry patches, and contact line dynamics leading to the boiling crisis in thin liquid film at droplet impact onto hot surfaces

Understanding and predicting the transition from nucleate boiling regime to the boiling crisis in a thin liquid film is important for numerous applications, such as the thermal management of power electronics and nuclear power plants. The processes of bubble coalescence, their br...

Control of semiconductor surface morphology and wettability via nanosecond laser texturing

Efficient thermal management in modern compact electronics requires surfaces with controlled wettability and strong wicking capability. Although laser-textured silicon is widely studied for its optical response, its wetting and capillary transport properties remain less explored....

Influence of mechanical vibration on nucleate boiling heat transfer at different pressures

The paper presents results of experimental study on the influence of mechanical vibration on heat transfer and evaporation dynamics in nucleation boiling of saturated water (for the pressure interval 10 – 101.3 kPa). Relevance of the study is due to a demand in increasing the hea...

Highly Contiguous Is Not Chromosomally Accurate: Integrated Cytogenetic and Genomic Mapping in Two Turtle Genome

Abstract High-quality genome assemblies are essential for robust research across biological and medical fields. Assembly errors can have far-reaching consequences for downstream analyses, including gene annotation and the inference of synteny. In contrast to the rapid growth of g...

Tuning the Anticancer Activity of Gold(I) Complexes via Redox-Active Ar-Bian Ligands: Experimental and Theoretical Insights

Abstract A series of cationic gold(I) complexes of the type [Au(PPh3)(Ar-Bian)](CF3SO3) based on 1,2-bis[(2,4,6-trimethylphenyl)imino]acenaphthene (tmp-Bian), 1,2-bis[(4-chlorophenyl)imino]acenaphthene (4–Cl-C6H4–Bian), 1,2-bis[(4-bromophenyl)imino]acenaphthene (4–Br-C6H4–Bian),...

On the Age and Genesis of the Verkhnyaya Gora Strata of the Kurtak Region, Middle Yenisei

Abstract A study of the geology of the Verkhnyaya Gora strata in the Berezhekovo-5 section of the Kurtak geoarcheological region, based on numerous detailed outcrops, shows its deluvial-solifluctional genesis. The results of the analysis of the therio- and malacofaunas from the V...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Remediation of phenol and p-nitrophenol from contaminated water using raw and quaternized Annona muricata L. peels

Phenol and p -nitrophenol (PNP) are toxic, widely occurring phenolic pollutants requiring cost-effective removal methods. This study evaluates raw Annona muricata L. peels (RGP) and peels chemically quaternized (QGP) as low-cost biosorbents for phenol and PNP remediation from aqu...

Deep Methane Oxidation over Pd–Glass Fiber Catalysts Prepared by Chemical Vapor Deposition

Abstract Using chemical vapor deposition (CVD) and the traditional method of incipient wetness impregnation, new Pd–glass fiber catalysts (GFCs) for the oxidation of volatile organic compounds (VOCs) were synthesized. GFC samples were characterized by physicochemical methods (SEM...

Circulating anti-Ro/SSA-antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis

Abstract Backgrounds Accumulating evidence indicates that anti-Ro/Sjögren’s syndrome-related antigen A(SSA)-antibodies, specifically the anti-Ro/SSA-52kD subtype, can promote heart rate-corrected QT interval(QTc) prolongation by inhibiting the hERG-K+ channel. However, the numero...