Novo Nordisk Foundation

The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation

The ribosome is a universally conserved and essential molecular machine. While the core process of ribosome biogenesis is conserved across eukaryotes, metazoans have evolved additional regulatory factors. Here, we performed a protein–protein interaction screen of endogenously aff...

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...

Feasible geological carbon dioxide storage projections require updated cost and geological potential assumptions

Integrated Assessment Models project large-scale deployment of carbon dioxide geological storage across many climate change mitigation pathways. However, the feasibility of these projections - particularly concerning near-term scale-up rates - has been criticised. Here, we examin...

Predicting future risk of type 1 and type 2 diabetes after gestational diabetes mellitus using polygenic scores: a cohort study

AIMS/HYPOTHESIS: Women with previous gestational diabetes mellitus (GDM) have an increased risk of developing both type 1 and type 2 diabetes. However, predicting the risk on a personal level is challenging. Polygenic scores (PGSs), which capture an individual's genetic susceptib...

Stochasticity in response to rostrocaudal and mediolateral determinants influences inaccurate specification within kidney organoids

The differentiation of human pluripotent stem cells to kidney requires the accurate recapitulation of complex morphogenetic patterning events within an in vitro environment. Current protocols are assumed to accurately pattern through intermediate mesoderm to kidney with outcomes...