Nova Scotia Health Authority

Analysis of immediate upstream gene regions in orthopoxvirus genomes through the use of DNA Duplex Stability and explainable machine learning

Orthopoxviruses are double-stranded DNA viruses with a temporally regulated gene expression program divided into early, intermediate, and late stages. Although many temporal gene functions are known, the promoter features that distinguish expression program require more precise c...

Design and development of AbortionCareTXT, a text message programme for individuals undergoing medication abortion

Abstract Background In Canada, medication abortion accounts for approximately 30% of the 100 000 annual abortions. Despite the advantages of privacy and autonomy, many individuals report feeling unprepared and uninformed about the medication abortion process. Mobile health (mHeal...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

A prospective split-scar randomized controlled trial of post-operative silicone tape improves scar appearance

Topical silicone dressings show promise in improving scar appearance in procedural scars; however, limited high-quality evidence exists. This randomized controlled trial (RCT) aimed to determine the efficacy of silicone tape (3 M Kind Removal Silicone Tape 2770) as a simple affor...

Chronic Pain Uncouples Functional Brain Network Segregation From Cognitive Performance in Aging

Introduction Chronic pain (CP) disproportionately affects older adults, not only because it is more prevalent in later life, but also because it may exacerbate cognitive aging and is associated with increased dementia risk [1]. Recent research has implicated accelerated brain agi...

Feasibility, Acceptability and Outcomes of Group CBT ‐T: A Naturalistic Mixed‐Methods Comparison With Individual CBT ‐T

ABSTRACT Objective This study aimed to evaluate the feasibility of implementing 10‐session group cognitive behavioural therapy (CBT‐Tg) in routine outpatient eating disorder care and to descriptively examine outcomes of CBT‐Tg and individual CBT‐T (CBT‐Ti). Method Using a natural...

Lamotrigine and other therapy-associated HLH syndromes: a review

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation that can occur secondary to medical interventions including immunomodulatory therapies such as immune checkpoint inhibitors and stem cell transplantation. However, lamotrigine and...