Nottingham University Hospitals NHS Trust

P1.201. Textbook Outcome After Oesophago-Gastric Cancer Surgery: Temporal Change Over 24 Years and Association With Survival

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Outcomes after oesophago-gastric cancer surgery have improved over the last two decades, but it is unclear whether this reflects fewer complications, improved s...

P1.200. Reducing Failure to Rescue Improves Long Term Survival After Oesophago-Gastric Cancer Surgery

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Outcomes after oesophago-gastric cancer surgery have improved over time, and this is likely to be multifactorial. In addition to better oncologic treatments, sa...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Urinary Extracellular Vesicles as a Source of Biomarkers for Kidney Allograft Rejection: A Systematic Review

BACKGROUND: Kidney transplant rejection remains a leading cause of graft loss, and diagnosis still depends largely on invasive biopsies. Urinary extracellular vesicles (uEVs) offer a potential noninvasive alternative for detecting allograft rejection through molecular profiling o...

Maximizing stem body size may reduce the risk of postoperative periprosthetic fractures

Aims: There is concern around an increased risk of postoperative periprosthetic fracture (POPPF) with cemented polished taper slip (PTS) femoral components. We hypothesized that femoral constructs resulting in increased load on the cement mantle would be associated with higher PO...

Does pre-operative neutrophil–lymphocyte ratio predict patient-reported pain and functional outcomes at 12 months after anterior cervical discectomy and fusion?

INTRODUCTION: Preoperative neutrophil-lymphocyte ratio (NLR) has been found in various fields to be a predictor of post-operative pain and functional outcomes. To date no studies have looked at NLR in relation to patient outcomes after anterior cervical discectomy and fusion (ACD...

Swallowing therapy for dysphagia in acute and subacute stroke

RATIONALE: Post-stroke dysphagia ((PSD) impaired swallowing following stroke), increases risk of death, yet the effects of potential treatments are unclear. This review updates the 2018 review. OBJECTIVES: To assess the effects of swallowing therapies on swallowing impairment (SI...

Protein-Containing Breakfasts Are Associated with Reduced Postprandial Glycaemic Excursions in Children and Young People with Type 1 Diabetes: A Pragmatic Study

Background/Objectives: This study examined whether adding 10 g of protein to a high glycaemic index (GI) breakfast could attenuate postprandial glycaemic responses in children and young people (CYP) with type 1 diabetes (T1D). Postprandial glucose responses following this modifie...

Non-medical surgical delay increases one-year mortality following hip fracture

Aims: This study aimed to assess the association between surgical delay due to non-medical reasons and one-year mortality in patients with hip fracture, and to explore whether a dose-response relationship exists between increasing time to surgery and mortality risk. Methods: A re...