Nottingham Biomedical Research Centre

A scoping review of digital health technologies in glycogen storage diseases

Abstract Glycogen storage diseases (GSDs) are rare inherited metabolic disorders requiring complex management. Digital health technologies (DHTs) offer solutions for improving care delivery, yet their implementation remains poorly characterised. This scoping review systematically...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Efficacy of topical vancomycin in preventing surgical site infection following fracture surgery

Aims Fracture-related infection (FRI) is a major cause of morbidity following limb fracture surgery. Topical vancomycin has gained popularity as an adjunct to systemic prophylaxis; however, concerns regarding nephrotoxicity, impaired bone healing, and wound complications remain....

Targeted community screening in areas of high socioeconomic deprivation enhances the detection of liver fibrosis.

BACKGROUND: Risk-factor-based community screening has been used to identify early liver disease. Risk-factor prevalence and liver-related outcomes are significantly affected by socioeconomic deprivation. However, the impact on targeted community screening is unknown. We evaluated...

An exploratory economic assessment of the effect of the smoke‐free generation policy in England on smoking in pregnancy

AIMS: To estimate the impact of England's proposed smoke-free generation (SFG) policy on smoking at time of delivery, adverse maternal and offspring outcomes and the cost-effectiveness of the policy compared with no intervention. DESIGN: Decision analytic modelling using the Econ...

The effect of pectin supplementation on geriatric individuals with frailty: a randomised placebo-controlled dietary intervention study

Abstract Frailty is associated with impaired physical function, psychological decline, and alterations in the gut microbiome, yet nutritional strategies targeting these interconnected pathways remain limited. Low-methoxy (LM) pectin, a fermentable dietary fibre derived from plant...

How have contemporary studies evaluating self-help digital mental health interventions for young people monitored and reported on adverse events and harms?: a systematic scoping review

Background Many digital mental health interventions (DMHIs) can be effective in reducing symptoms of common mental health problems in young people and can overcome many barriers to accessing treatment. These are most scalable when offered as self-help. However, all mental health...

Occupational health challenges in commercial diving: a qualitative study of psychological risk, training gaps, and organisational responsibilities

Introduction: Little is known about the occupational health needs of commercial divers, particularly regarding psychological wellbeing, trauma exposure, organisational support, and the adequacy of training for high‑risk environments. This study qualitatively explored pathways int...

Poverty alleviation for people with severe mental health conditions in South Africa: A qualitative study

People with severe mental health conditions (SMHC) and caregivers in South Africa often experience poverty. The PRIZE trial found that recovery groups were acceptable, feasible and potentially effective in reducing relapse. Addressing economic needs was identified as a means to i...

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

Urinary Extracellular Vesicles as a Source of Biomarkers for Kidney Allograft Rejection: A Systematic Review

BACKGROUND: Kidney transplant rejection remains a leading cause of graft loss, and diagnosis still depends largely on invasive biopsies. Urinary extracellular vesicles (uEVs) offer a potential noninvasive alternative for detecting allograft rejection through molecular profiling o...

Non-medical surgical delay increases one-year mortality following hip fracture

Aims: This study aimed to assess the association between surgical delay due to non-medical reasons and one-year mortality in patients with hip fracture, and to explore whether a dose-response relationship exists between increasing time to surgery and mortality risk. Methods: A re...