NOSM University

High-Dose Gestational Irradiation Disrupts Fetal Mouse Brain Structure and Region-Specific Transcriptomic Profiles

Background/Objectives: Prenatal exposure to ionizing radiation can disrupt neurodevelopment, yet the region-specific structural and molecular responses of the developing brain remain incompletely understood. In particular, how gestational irradiation alters transcriptional progra...

Circulating Tumor DNA (ctDNA) for Minimal Residual Disease (MRD) Detection in Colorectal Cancer (CRC): Current Evidence, Clinical Applications, and Future Directions

Minimal residual disease (MRD) is a major contributor to colorectal cancer (CRC) recurrence following curative-intent treatment, yet conventional surveillance methods may fail to detect residual disease at its earliest stages. Circulating tumor DNA (ctDNA) has emerged as a minima...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Addressing the Knowledge to Practice Gap in Cultural Safety Training Among Medical Students: The Beading Cultural Safety Project

Indigenous ways of knowing and doing are well-situated to engage future health service providers in cultural safety, yet there has been limited research in this area. This paper reports findings from an Indigenous participatory research project exploring the impact of beadwork on...

Effectiveness of Adding GLP ‐1 Receptor Agonists to SGLT2 Inhibitor Therapy in Chronic Kidney Disease: A Population Based Study

ABSTRACT Background Individually, sodium–glucose co‐transporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have been shown to reduce major kidney and cardiovascular events in patients with chronic kidney disease (CKD). However, evidence support...

Treatment outcomes after initiating buprenorphine/naloxone or methadone for opioid use disorder among First Nation Peoples in Ontario, Canada

Background The Canadian opioid toxicity crisis has disproportionately harmed First Nation Peoples. We compared opioid agonist treatment (OAT) outcomes within this population. Methods Our population-based cohort included First Nation Peoples in Ontario, Canada, who initiated bupre...

Smart Lithotripsy: Lasers, Energy Sources and Efficiency

PURPOSE OF REVIEW: To examine the evidence on contemporary lasers and provide a practical framework for platform selection, parameter optimization, and thermal safety based on the principles of smart lithotripsy. RECENT FINDINGS: Holmium: yttrium-aluminum-garnet (Ho:YAG) remains...

Accuracy of Rome IV questionnaire: a population-based study on diagnostic definitions and clinical validity

Rome IV questionnaire is widely used for diagnosing disorders of gut-brain interaction (DGBIs), but was developed in Western populations and may not generalize to other regions. This study aimed to validate the Persian version of this questionnaire and develop population-adapted...

Role of consolidative surgery after chemotherapy in recurrent/metastatic adrenal cortical cancer (ACC): Princess Margaret Cancer Centre experience

Recurrent/Metastatic (R/M) ACC is aggressive with few effective treatment options. The role of surgery after chemotherapy remains unclear. Moreover, prognostic factors in R/M ACC are not well defined. R/M ACC patients treated at Princess Margaret Cancer Centre (2002–2019) were re...