Northwestern Medicine

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Assessing the estimands and estimates of hospitalization rates in health economics and clinical medicine

Even though data on hospital admissions are widely used in health research, hospitalization‐related estimands measured using these data are not always clearly conceptualized. Consequently, estimators of these quantities can have unclear rationales and undesirable properties. We e...

The Heart of the Matter — Transforming Congenital Heart Disease Care through Patient-Reported Outcomes

Patients with congenital heart disease (CHD) face substantial challenges in managing their chronic illness. Common and often unmet needs include neurocognitive challenges, mental health conditions, multiorgan disease, school and work impairment, and financial constraints. To impr...

Epithelial-mesenchymal Wnt crosstalk directs planar cell polarity in the developing cochlea

Cochlear hair cells are precisely oriented by planar cell polarity. Wnt proteins direct planar cell polarity in vertebrates, but their roles in regulating cochlear planar cell polarity remain unclear. Here, we inhibit Wnt secretion by ablating epithelial Wntless and find shortene...

Interactive Panometry: Using Proximal Balloon Distension During Functional Lumen Imaging Probe Panometry to Enhance Motility Evaluation of Inhibitory Function

Background/Aims: : Descending inhibition facilitates esophageal peristalsis and lower esophageal sphincter relaxation, processes impaired in achalasia. The functional lumen imaging probe (FLIP) assesses esophageal motility and esophagogastric junction (EGJ) opening but does not d...

Reconceptualizing Cerebral Palsy as a Lifelong Condition Characterized by Systemic and Accelerated Biological Decline

Cerebral palsy (CP), the most common childhood-onset disability worldwide, affects an estimated 50 million individuals globally. Although most individuals with CP are adults, CP education and training remain heavily concentrated within pediatric subspecialties, contributing to su...

A memorial tribute to Dr. Asgerally T. Fazleabas

Gregory W Burns, Yong Song, J Julie Kim; A memorial tribute to Dr. Asgerally T. Fazleabas, Biology of Reproduction, , ioag180, https://doi.org/10.1093/biol

Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults

BACKGROUND: Whether isolated diastolic hypertension (IDH) in young adults represents a benign, age-specific phenotype or confers increased cardiovascular disease risk remains uncertain. We assessed the associations between hypertension subtypes, IDH, isolated systolic hypertensio...

Within-Person Sweat Chloride Variability in People with Cystic Fibrosis Measured via Wearable Microfluidic Sticker

Melissa H Ross, Thaddeus Cybulski, Rachel S Nelson, Roozbeh Ghaffari, John A Rogers, A J Aranyosi, Garett J Griffith, Daniel M Corcos, Manu Jain; Within-Pe