Northern Jiangsu People's Hospital

U-shaped association of platelet-to-lymphocyte ratio with all-cause and cardiovascular mortality in hypertension: mediating role of renal dysfunction in a nationwide cohort (NHANES 2005–2018)

To evaluate the association between the platelet-to-lymphocyte ratio (PLR) and all-cause and cardiovascular mortality among adults with hypertension in the National Health and Nutrition Examination Survey (NHANES). We conducted a prospective cohort analysis using NHANES 2005–2018...

Cross-cultural validation and latent profile analysis of the self-efficacy for home exercise programs scale in patients after arthroscopic rotator cuff repair

This study aims to cross-culturally adapt and validate the Self-Efficacy for Home Exercise Programs Scale (SEHEPS) for Chinese patients after arthroscopic rotator cuff repair (ARCR), and to explore the latent profiles of their home exercise program (HEP) self-efficacy as well as...

FGF-23 is associated with increased risk of abdominal aortic calcification

Fibroblast growth factor 23 (FGF23) is involved in the regulation of phosphate metabolism and has been linked to vascular calcification. However, the genetic association between FGF23 and abdominal aortic calcification (AAC) remains unclear. We conducted a bidirectional two-sampl...

Metabolite-based Analysis of High-Risk Factors on Occurrence of AKI in Patients with Acute Myocardial Infarction

Current methods lack high‑risk identification for acute kidney injury (AKI) after acute myocardial infarction (AMI). This study aimed to develop a metabolic‑biomarker‑based predictive system. 124 AMI patients (July 2023–October 2024) were enrolled prospectively. Logistic regressi...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

Coronary plaque phenotypes, inflammation and cardiovascular prognosis in metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) correlates with cardiovascular events. We sought to assess the association of coronary computed tomographic angiography (CCTA)-detected high-risk plaque characteristics (HRPC) and coronary inflammation with MASLD an...

Early ionized calcium changes after postoperative blood product transfusion in adult cardiac surgical ICU patients: a retrospective database study

Ionized calcium (iCa) is frequently measured after adult cardiac surgery, but the clinical implications of early post-transfusion changes are uncertain. We evaluated early iCa change as a transfusion-associated measurement pattern rather than as proof of blood-product causality o...

Monocyte-to-HDL cholesterol ratio and cardiovascular comorbidity in COPD

Chronic obstructive pulmonary disease (COPD) is frequently complicated by cardiovascular disease (CVD), which significantly increases morbidity and mortality. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as a novel inflammatory biomarker associated...

Safety and prognosis of pancreaticoduodenectomy in HBsAg-positive patients based on propensity score matching analysis: a retrospective study

Due to the lack of reliable evidence regarding pancreaticoduodenectomy (PD) in patients with hepatitis B virus (HBV) infection, it is necessary to clarify the impact of HBV on patients subjected to PD. A total of 201 patients were enrolled and divided into two groups according to...

Diagnostic performance of ultrasound-measured visceral fat thickness and metabolic indices for MRI-PDFF-defined hepatic steatosis in MAFLD

Metabolic dysfunction-associated fatty liver disease(MAFLD) has emerged as a globally significant liver disorder due to its continuously rising prevalence. Our aim is to investigate the clinical value of ultrasound-measured visceral fat thickness (VFT) and five scoring systems—fa...

Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma

Accurately predicting the risk of early liver metastases (ELM) and identifying patients who are most likely to benefit from neoadjuvant therapy (NAT) are critical for pancreatic ductal adenocarcinoma (PDAC). Here, we develop a Mamba-based predictive model that integrates imaging...

Polygenic risk score analysis for major depressive disorder in a Chinese cohort: single-phenotype and pathway-based approaches

Abstract Background Major depressive disorder (MDD) is a global mental health challenge characterized by high prevalence, disability, and recurrence, with its susceptibility showing substantial polygenic inheritance. Polygenic risk scores (PRS) provide a novel method to explore c...

Comparative effects of vonoprazan-based and esomeprazole-based dual therapy on Helicobacter pylori eradication and short-term gut microbiota changes

Abstract Objective This study aimed to compare the Helicobacter pylori (H. pylori) eradication efficacy, safety, patient compliance, and short-term effects on the gut microbiota of vonoprazan-based potassium-competitive acid blocker (P-CAB) dual therapy and esomeprazole-based pro...

Decoding hypoxia-driven microenvironment remodeling in bladder cancer reveals TPST1 as a key driver of metastasis

Hypoxia is a key feature of the bladder cancer tumor microenvironment, but its cellular organization, prognostic value, and functional effectors remain incompletely defined. Here, we integrated single-cell RNA sequencing, bulk transcriptomic cohorts, machine-learning modeling, im...

A Validated, explainable machine learning–based preoperative risk model for microvascular invasion in hepatocellular carcinoma

Abstract Purpose This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Methods Clinical and pathological information of patients with HCC...

Long-term workload, changing injury patterns, and spring festival-related case mix among patients hospitalized with open globe injury at a Chinese tertiary referral centre, 2013–2025

Abstract Background Open globe injury (OGI) is vision-threatening, but long-term changes in hospitalized workload and injury patterns remain poorly characterized. We assessed temporal changes in OGI workload and relative inpatient burden and whether the Spring Festival was associ...

P53 Competitively Binds P300 to Suppress HIF ‐1α/ TFRC ‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

ABSTRACT Doxorubicin (DOX) resistance limits the efficacy of chemotherapy in breast cancer, and suppression of ferroptosis may contribute to this process. This study investigated the role of the Tumor Protein P53 (P53)/E1A‐associated protein P300 (P300)/Hypoxia‐inducible factor‐1...

Latent profiles of perceived digital convenience and their associations with depressive symptoms among Chinese empty-nest older adults: evidence from the 2023 CLASS

Digital technology is increasingly discussed as a potential resource for supporting mental health in later life, yet empirical findings remain mixed. Prior studies have largely relied on variable-centered approaches that may obscure how perceived convenience of digital activities...

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

ABSTRACT Iron–sulfur (Fe–S) clusters are pivotal molecular cofactors bridging inorganic chemistry and organic life processes, with their tightly regulated biosynthesis and function underpinning cellular metabolic homeostasis. Chronic alcohol‐induced metabolic stress impairs Fe–S...

Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiophobia Among Patients with Coronary Heart Disease: A Cross-Sectional Study

Jingwen Qin, Jiamin Li, Yan Zhou, Ping Yu, Xin Wang, Xin Pan, Kaizheng Gong; Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiop