Northern Jiangsu People's Hospital

Long-term workload, changing injury patterns, and spring festival-related case mix among patients hospitalized with open globe injury at a Chinese tertiary referral centre, 2013–2025

Abstract Background Open globe injury (OGI) is vision-threatening, but long-term changes in hospitalized workload and injury patterns remain poorly characterized. We assessed temporal changes in OGI workload and relative inpatient burden and whether the Spring Festival was associ...

Latent profiles of perceived digital convenience and their associations with depressive symptoms among Chinese empty-nest older adults: evidence from the 2023 CLASS

Digital technology is increasingly discussed as a potential resource for supporting mental health in later life, yet empirical findings remain mixed. Prior studies have largely relied on variable-centered approaches that may obscure how perceived convenience of digital activities...

P53 Competitively Binds P300 to Suppress HIF ‐1α/ TFRC ‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

ABSTRACT Doxorubicin (DOX) resistance limits the efficacy of chemotherapy in breast cancer, and suppression of ferroptosis may contribute to this process. This study investigated the role of the Tumor Protein P53 (P53)/E1A‐associated protein P300 (P300)/Hypoxia‐inducible factor‐1...

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

ABSTRACT Iron–sulfur (Fe–S) clusters are pivotal molecular cofactors bridging inorganic chemistry and organic life processes, with their tightly regulated biosynthesis and function underpinning cellular metabolic homeostasis. Chronic alcohol‐induced metabolic stress impairs Fe–S...

Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiophobia Among Patients with Coronary Heart Disease: A Cross-Sectional Study

Jingwen Qin, Jiamin Li, Yan Zhou, Ping Yu, Xin Wang, Xin Pan, Kaizheng Gong; Distinct Profiles of Heart-Focused Anxiety and Their Association with Kinesiop

MXene-Based Conductive Microneedle Patch Promotes Diabetic Wound Healing by Regulating Oxidative Stress and Immune Microenvironment

Abstract Excessive reactive oxygen species (ROS) generation and the release of inflammatory mediators create a pathological microenvironment in diabetic wounds, severely impairing the healing process. Coupling endogenous electric fields has shown great therapeutic potential for i...

Exploring the attributes of organizational health literacy in Chinese healthcare institutions from the perspective of the social-ecological theoretical model: a grounded theory study

Organizational health literacy (OHL) is essential for reducing adverse outcomes associated with limited health literacy, including medication errors, increased hospitalization, and widening health disparities. Although the complexity of the healthcare system represents a major ba...

Predictive value of C-reactive protein for progression from prehypertension to hypertension: a prospective cohort study based on the CHARLS database

Abstract Background The key to preventing and treating hypertension is predicting the progression of prehypertension and implementing preventive and control measures. Whether C-reactive protein (CRP) can predict the progression from prehypertension to hypertension remains to be c...

Factors associated with Gleason score upgrading in biopsy-proven Gleason 6 prostate cancer: a retrospective cohort study

The present study aims to evaluate the incidence and risk factors of postoperative pathological upgrading in patients with biopsy Gleason score 6(bGS6), and to explore whether relevant clinical parameters can stratify patients at high risk of upgrading. A total of 241 patients wh...

Nomogram for predicting the response of modified electroconvulsive therapy in patients with bipolar depressive episodes: a retrospective cohort study

Depressive episodes are a major manifestation of bipolar disorder, a common mental illness associated with substantial morbidity and premature mortality. Modified electroconvulsive therapy (MECT) is an effective physical treatment for bipolar depressive episodes. However, the cli...