Northern Hospital

Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease

Abstract Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s disease (AD). To address the limited brain penetration of our earlier lead ZJCK-6...

Ketamine for Analgosedation in Mechanically Ventilated Adults: A Double-Blind Randomized Trial

OBJECTIVES: The role of ketamine for analgosedation in the ICU remains unclear. This study aimed to assess the efficacy of low-dose ketamine infusion for adjunct analgosedation in adults receiving mechanical ventilation. DESIGN: A prospective, double blind, randomized, placebo-co...

Co-designed development of a vocational education and training program for peer health and social care navigators in Australia

<title>Abstract</title> Background Peer health navigators (lay patient navigators) are increasingly used to support consumers to access and navigate health and social care systems, particularly for populations experiencing barriers to care. Despite growing evidence of their effec...