North-Western State Medical University named after I.I. Mechnikov

Distinguishing relapse from sustained remission in acute myeloid leukemia. Lineage-specific developmental stage distributions

We characterize bone marrow cell populations at minimal residual disease (MRD) by their distribution across hematopoietic developmental stages within each major lineage. Using the BoneMarrowMap atlas (263.159 reference cells, 24 broad cell types) as a coordinate system, we assign...

Bowel preparation for colonoscopy: current strategies. A narrative review

Objective. To summarize current evidence on the principles of bowel preparation for colonoscopy. Key points. The quality of bowel cleansing is an independent quality indicator of colonoscopy and affects mucosal visualization, detection of colorectal neoplasia, and the need for re...

The “Dove Drawing” Appearance of the Ilium in Spondyloepiphyseal Dysplasia Congenita: A Proposed Radiographic Sign

Recognizable radiographic signs aid in the differential diagnosis of skeletal dysplasias. Spondyloepiphyseal dysplasia congenita (SEDC), a COL2A1-related disorder, presents with characteristic but sometimes subtle pelvic changes in early childhood. To propose a novel pelvic radio...

Management of Hip Instability in Spinal Muscular Atrophy in the Disease-Modifying Therapy Era: The “Late Autumn” or “Early Spring” of Neuro-Orthopedics?

Neuro-orthopedics is a field comprising knowledge and methods aimed at the diagnosis and treatment of secondary musculoskeletal disorders resulting from primary nervous system pathology. Historically, the greatest step in its development was associated with overcoming the consequ...

Interaction of Innate Immunity and Candida albicans Virulence Factors in the Regulation of the NLRP3 Inflammasome in Recurrent Vulvovaginal Candidiasis

Abstract Objective: Recurrent vulvovaginal candidiasis (RVVC) is currently considered an immunopathological process. Fungal virulence factors and host immune responses, such as NLRP3 inflammasome activation, are thought to play an important role in the development of hyperinflamm...

A historical review of cortical auditory evoked potentials

Long-latency (or cortical) auditory evoked potentials (LLAEP/CAEP) reflect the cortical processing of acoustic signals. This method is currently utilized in audiological, neurological and neurolinguistics research. LLAEP were first discovered serendipitously in 1939 during neurop...

Machine Learning-Assisted SHG Morphometry Reveals Distinct Collagen Microarchitectures of Trabecular Bone and Fibrosis in Bone Marrow Biopsies

Abstract Collagen microarchitecture in bone marrow biopsies represents a largely underexplored source of quantitative biomarkers for histopathological diagnostics and analysis of tissue remodeling. While second harmonic generation (SHG) microscopy has been increasingly applied to...

The depth of wound channels of stab wounds of the chest and abdomen as an indicator of the force of a knife strike

The length of the wound channel of a stab wound is a morphological feature that can serve as a criterion for assessing the degree of force of a knife strike. A study of 412 stab wounds to the chest and abdomen in 252 homicide cases showed that clothing, bone-cartilaginous structu...