North Shore Hospital

Circulating biomarkers in the diagnosis and management of neuroendocrine neoplasms

Abstract Neuroendocrine neoplasms (NENs) comprise a broad family of tumours arising from the diffuse neuroendocrine system and endocrine glands, and vary widely in clinical behaviour ranging from indolent to highly aggressive. Established monoanalyte biomarkers including chromogr...

Irritability: what, who, how and why?

Irritability is a ubiquitous clinical phenomenon, and yet its definition and specific role within psychiatric disorders have long eluded the field. By understanding what irritability is, in whom it should be studied and how it should be modelled, new insights into the disorders w...

PREOPERATIVE PAIN SENSITIVITY HAS A GREATER IMPACT ON CLINICAL OUTCOMES THAN CORONAL ALIGNMENT STRATEGY IN ROBOTIC-ASSISTED TOTAL KNEE ARTHROPLASTY: IMPLICATIONS FOR TRIAL DESIGN

Introduction Both pre-operative pain sensitivity and coronal alignment philosophy may influence patient-reported outcomes (PROMs) after total knee arthroplasty (TKA). This study investigated whether pain sensitivity predicts function in robotic-assisted TKAs 19andomized to functi...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Use of pH Testing to Confirm Feeding Tube Placement: A Quality Improvement Project

BACKGROUND: Chest radiography confirms initial nasogastric tube placement but is impractical for repeated verification during feeding and medication administration. LOCAL PROBLEM: Nasogastric tube placement verification practices on the neuroscience unit delayed feedings and medi...

Clinical efficacy to climate accountability

There is increasing global recognition of the importance of sustainability in the design and delivery of healthcare, including trauma and orthopaedics. There has, however, to date been little focus on providing high-quality research which includes environmental outcomes to guide...