North Karelia Central Hospital

Epidemiological associations between neurodegeneration and cancer – time to refine our research approach

Cancer and neurodegenerative diseases are devastating aging-related disorders. Epidemiological data suggest a general inverse risk association between them, the mechanisms of which might provide new avenues for developing treatments and prevention strategies. In addition to this...

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

This is the first report of neuropathology in biallelic RFC1 expansion-associated Parkinson's disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bila...