North China University of Science and Technology Affiliated Hospital

Prognostic Evaluation of Acute Ischemic Stroke Patients After Mechanical Thrombectomy Incorporating Imaging, Inflammatory, and Rehabilitation Aspects

AIM: We aimed to perform a prognostic evaluation for patients with acute ischemic stroke after mechanical thrombectomy (MT) incorporating imaging, inflammatory, and rehabilitation aspects.METHODS: A retrospective cohort analysis of patients with acute ischemic stroke (AIS) after...

Moral courage in nursing students before internship: A network analysis

Background Moral courage helps nursing students respond to ethically difficult situations, yet little is known about how its dimensions relate to ethical sensitivity, professional identity, and emotional intelligence at the dimension level. Research objective This study examined...

Plasma Glutamine and Glutamate in Relation to Clinical Outcomes After Ischemic Stroke: A Multicenter Prospective Study

Background Glutamine (Gln) and glutamate (Glu) have been suggested to play a pivotal role in neuronal homeostasis and metabolic regulation, showing potential as prognostic biomarkers for stroke. This study aimed to evaluate the associations of plasma Gln, Glu, and glutamine‐to‐gl...

Research Progress on Intraocular Pressure-lowering Drugs, Commonly Used Clinical Adjuvants, and Emerging Neuroprotective Agents for Glaucomatous Optic Neuropathy

Abstract Glaucomatous optic neuropathy (GON) is the leading cause of irreversible blindness worldwide, characterized by progressive retinal ganglion cell (RGC) loss. Current clinical treatment relies primarily on IOP-lowering drugs, but a subset of patients continues to experienc...

Comparing the efficacy of bronchial artery chemoembolization combined with anlotinib versus anlotinib alone in the treatment of advanced non-small cell lung cancer

To compare the clinical effectiveness and safety of addition of anlotinib to bronchial artery chemoembolization (BACE) compared to anlotinib alone in the treatment of stage IIIA-IIIB non-small cell lung cancer (NSCLC) with no mutated driver genes. The clinical data of patients wi...

Mechanistic study on the regulation of hepatocellular carcinoma progression by GNAI2 possibly through the PI3K/AKT pathway

Hepatocellular carcinoma (HCC), the most common form of liver cancer, remains poorly understood in terms of its underlying mechanisms. The protein GNAI2 has been shown to regulate the transcription of multiple biomolecules and is thought to contribute to the onset and progression...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...