North China University of Science and Technology Affiliated Hospital

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...