Nishtar Medical College and Hospital

Superior sagittal sinus thrombosis in hemoglobin S–D disease with acute pyogenic meningitis: a rare case report

Cerebral venous sinus thrombosis (CVST) involving the superior sagittal sinus with associated cerebral infarction is an exceptionally rare neurological complication of hemoglobin S–D disease. The heterogeneity of clinical manifestations, overlapping infective and hematologic feat...

Efficacy of rituximab plus lenalidomide regimens in follicular lymphoma: a meta-analysis of randomized controlled trials

Follicular lymphoma (FL) is an incurable, indolent non-Hodgkin lymphoma with a high relapse rate despite effective chemoimmunotherapy. Lenalidomide, an immunomodulatory agent, in combination with rituximab (R²), has been evaluated as an alternative to chemoimmunotherapy and to ot...

Comparative efficacy and safety of oral iron polymaltose complex vs. ferrous sulphate in the treatment of pediatric iron deficiency anemia: a systematic review, meta-analysis and trial sequential analysis

Oral iron supplementation is the first-line therapy for pediatric iron deficiency anemia (IDA). Ferrous sulphate (FS) remains the conventional standard of care but frequently induces gastrointestinal (GI) adverse effects. Iron polymaltose complex (IPC) has emerged as an alternati...

Temporal trends and demographic disparities in constipation-associated mortality in the United States, 1999–2024

Constipation is common and managed as benign; however, refractory disease can progress through fecal impaction to stercoral colitis, perforation, and sepsis. The national mortality trends are unmapped. Serial cross-sectional CDC WONDER multiple-cause analysis, US adults ≥ 25 year...

Profiling motivation, stress, and empathy in distinct stages of medical education

Medical Education is one of the most demanding disciplines worldwide. Motivation, perceived stress, and empathy are three core structures that shape medical student’s academic performance, psychological well-being, and quality of future patient care. Although these factors have b...

Ropeginterferon alfa-2b in Polycythemia Vera: A systematic review and meta-analysis

Background: Ropeginterferon alfa-2b, a novel monopegylated interferon with improved pharmacokinetics, has emerged as a promising cytoreductive agent for managing polycythemia vera (PV). Despite increasing adoption, evidence synthesis of its efficacy and safety compared to standar...

Cardiotoxicity and safety of zanubrutinib versus chemoimmunotherapy in chronic lymphocytic leukemia: a real-world retrospective cohort study using the TriNetX registry

Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults in the Western countries. Ibrutinib, a first-generation Bruton’s tyrosine kinase (BTK) inhibitor, is commonly used for relapsed/refractory CLL but is associated with cardiovascular adv...

Self-medication among higher education students: prevalence, risk factors, and health information-seeking behaviours

The WHO estimates that more than two-thirds of university students engage in this practice. This study aims to determine the prevalence, knowledge, attitudes, and practices related to self-medication, along with the determinants that influence these behaviors, among higher educat...