Nippon Medical School

Aspiration-line pressure stability in Venturi and peristaltic pump configurations during phacoemulsification: an in vitro study

This in vitro study descriptively evaluated aspiration-line pressure waveforms between Venturi and peristaltic pump configurations and their associated tubing systems using two Stellaris systems and a KITARO artificial anterior chamber model. VAC200 and VAC400 represented 200- an...

Effects of Switching From Deucravacitinib to Tildrakizumab in Psoriasis: A 28-Week Real-World Study

Background Deucravacitinib, a tyrosine kinase 2 inhibitor, has shown efficacy and tolerability in moderate-to-severe psoriasis. However, evidence on switching from deucravacitinib to an interleukin-23 inhibitor is limited. Objective We examined outcomes after switching from deucr...

Technical feasibility of AI-based longitudinal multi-organ volumetry on low-dose PET/CT over 13 years

Abstract Purpose This study aimed to (i) compare TotalSegmentator Fast and Normal inference modes on low-dose PET/CT, (ii) evaluate whether CT denoising improves segmentation longitudinal consistency, and (iii) examine whether the selected pipeline can capture long-term within-pa...

Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry

This study evaluated the clinical and demographic characteristics of biopsy-proven rapidly progressive glomerulonephritis (RPGN), with histological evidence of renal vasculitis. We focused on five vasculitis-related nephritides: MPO-ANCA, PR3-ANCA, anti-GBM, IgA vasculitis (IgAV)...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Histological Determinants of Atrial Dysfunction in Patients With Atrial Fibrillation

Background Atrial fibrillation (AF) is associated with diverse histological abnormalities, but their contributions to atrial dysfunction and functional recovery remain unclear. Methods In a discovery cohort of 375 patients with nonvalvular AF undergoing catheter ablation, atrial...

Aberrant expression of the PREX2–MAGI2 axis modulates myofibroblast differentiation in pulmonary fibrosis

Myofibroblast differentiation is a pivotal event in idiopathic pulmonary fibrosis (IPF) and is driven by TGF-β1–dependent PTEN destabilization; however, the intermediate regulators remain incompletely defined. We tested three lung fibroblast cell lines (one normal and two IPF-der...

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...

Associations of carboxypeptidase A1 and gamma-glutamyltransferase 1 genotypes with refractory functional dyspepsia: a potential link to pancreatic pathophysiology and refractory dyspepsia

Background and Aims This study aimed to investigate the associations between SNPs in CPA1, GGT1, and SPINK1 genes and the clinical characteristics of refractory FD including clinical symptoms, pancreatic enzyme abnormalities, and exocrine pancreatic function.Methods 97 Patients w...

Preoperative predictors of patient-reported outcomes after joint-preserving forefoot surgery for rheumatoid arthritis

Aims: Forefoot deformities are common in patients with rheumatoid arthritis (RA) and often impair quality of life. Patient-reported outcome measures (PROMs), including the Self-Administered Foot Evaluation Questionnaire (SAFE-Q), are increasingly used to assess surgical outcomes;...

Steerable microcatheter-assisted selective inflow embolization of a giant femoral artery bifurcation pseudoaneurysm: A case report

Femoral artery pseudoaneurysm is a known complication of arterial access, and its management can be particularly challenging in patients with severe coagulopathy or complex vascular anatomy. Here, we report a case of a giant femoral artery bifurcation pseudoaneurysm arising from...