Nippon Dental University Hospital

Effect of a corticotropin-releasing factor 1 receptor antagonist on head withdrawal thresholds in mice with chronic constriction injury of the infraorbital nerve

Objectives Corticotropin-releasing factor (CRF)-1 receptors are involved in acute stress responses, pain enhancement under stressful conditions, activation of the hypothalamic-pituitary-adrenal system, and induction of anxiety and fear. In this study, the aim was to clarify the i...