Ningxia Medical University General Hospital

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...

Latent Profiles of Post-Stroke Fatigue and Their Association with Anxiety, Depression, and Sleep in Patients with First-Ever Stroke: A Cross-Sectional Study

Objectives: This study aimed to identify latent profiles of post-stroke fatigue (PSF) and examined their associations with anxiety symptoms, depressive symptoms, and sleep quality among first-ever stroke survivors. Methods: From December 2023 to May 2024, participants were recrui...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...