Ningxia Medical University General Hospital

Preoperative aggregate index of systemic inflammation and cause-specific 1-year mortality after surgery for geriatric intertrochanteric fracture

Older adults undergoing intertrochanteric-fracture surgery have high 1-year mortality. Routine preoperative complete blood count indices may provide readily available prognostic information before surgery. This prospective single-center cohort enrolled consecutive patients aged ≥...

Cell-resolved spatial mapping of antibody-drug conjugate targets in breast cancer

Background Antibody-drug conjugate (ADC) activity and target-dependent on-target/off-tumor toxicity depends in part on which cells express the target antigen, a feature that bulk assays cannot resolve. Methods We analyzed a publicly available whole-transcriptome CosMx breast tumo...

A Simple Platelet-Centered Coagulation–Inflammation Combined Score for Predicting In-Hospital Mortality in Sepsis

OBJECTIVE: Accurate mortality prediction in sepsis requires assessing coagulation and inflammatory disturbances, yet existing scores are complex or incompletely capture these interconnected processes. We developed and internally validated a simple score combining inflammatory and...

Dose-conditioned machine-learning prediction of a composite target sedation state in patients undergoing propofol-sedated gastrointestinal endoscopy

BACKGROUND: During propofol-sedated gastrointestinal endoscopy, adequate sedation must be achieved without compromising hemodynamic stability or oxygenation. We developed and temporally validated dose-conditioned machine-learning models to predict a composite target sedation stat...

Prenatal paraben exposure and neonatal birth outcomes: The modifying role of mid‑to‑late pregnancy weight gain rate

Parabens are ubiquitous endocrine-disrupting chemicals. However, the effects of paraben mixtures on neonatal growth and the modifying role of post‑blood‑collection gestational weight gain rate (GWG_after) remain unclear. This prospective cohort included 934 mother-infant pairs fr...

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

The molecular mechanisms governing mRNA accumulation during oocyte growth, essential for developmental competence, remain poorly understood. This study investigates the role of Matrin-3 (MATR3), a highly expressed RNA-binding protein in growing oocytes (GOs), using oocyte-specifi...

Integrated multi-omics analyses reveal the role of PAXX in colorectal cancer progression and the tumor immune microenvironment

Abstract PAXX is a DNA double-strand break repair factor involved in classical non-homologous end joining. Although elevated PAXX expression has been reported in colon cancer, its functional role and downstream mechanisms in colorectal cancer (CRC) remain incompletely defined. Th...

Infrapopliteal runoff status predicts mid-term outcomes after endovascular popliteal artery aneurysm repair

This study aimed to evaluate mid-term outcomes after endovascular repair (EPAR) for popliteal artery aneurysms (PAAs), with a specific focus on identifying prognostic factors for adverse events after EPAR, particularly the impact of infrapopliteal runoff status. Open surgical rep...

Serum amyloid A on postoperative day 3 for early prediction of deep surgical site infection after degenerative spine surgery

Deep surgical site infection (dSSI) is a serious complication after degenerative spine surgery, and early postoperative risk identification remains challenging. This prospective single-center cohort study serially measured C-reactive protein (CRP), procalcitonin (PCT), and serum...

Multidimensional analysis of pulmonary blastoma: clinical, bibliometric and bioinformatic insights

Abstract Objective Pulmonary blastoma (PB) is a rare primary lung tumor, accounting for less than 0.5% of all lung cancers. Its epidemiological and clinical characteristics remain unclear, and the molecular pathogenesis had not been fully elucidated, which poses challenges to sta...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1‐Mediated Cuproptosis, While Promoting M2 Macrophage Polarization

ABSTRACT This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin‐conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC). Based on the TCGA and GEPIA databases, t...

Paulownin: a promising agent In the fight against the invasion and immune escape in triple-negative breast cancer

Background Breast cancer is the most prevalent malignancy among females. Paulownin has anti-tumor properties and immune-modulating activities in various cancers; however, its effects on breast cancer remain inadequately understood.Aims This study aimed to elucidate the impact of...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

Latent Profiles of Post-Stroke Fatigue and Their Association with Anxiety, Depression, and Sleep in Patients with First-Ever Stroke: A Cross-Sectional Study

Objectives: This study aimed to identify latent profiles of post-stroke fatigue (PSF) and examined their associations with anxiety symptoms, depressive symptoms, and sleep quality among first-ever stroke survivors. Methods: From December 2023 to May 2024, participants were recrui...