Ningxia Hui Autonomous Region Peoples Hospital

Cell-resolved spatial mapping of antibody-drug conjugate targets in breast cancer

Background Antibody-drug conjugate (ADC) activity and target-dependent on-target/off-tumor toxicity depends in part on which cells express the target antigen, a feature that bulk assays cannot resolve. Methods We analyzed a publicly available whole-transcriptome CosMx breast tumo...

HIA-MTL: A dynamic hard task mining approach for breast and multi-organ histopathological image classification

Breast cancer is the most common cancer among women worldwide, and its accurate classification based on digital pathology images is crucial for improving treatment precision. However, breast histopathology image classification faces challenges such as coarse-grained annotations a...

Norepinephrine Induces Inflammation- and Injury-Related Changes in Epicardial Adipose-Derived Cells via the p38 MAPK and NF-κB Signaling Pathways and Is Associated With Calcium-Handling Protein Changes and Cellular Injury in H9c2 Cells Exposed to Epicardial Adipose-Derived Cell Culture Media

Background: Norepinephrine may induce inflammatory changes and cellular injury in epicardial adipose-derived cells. This study investigated the effects of norepinephrine on these cells and examined calcium-related responses and cellular injury in H9c2 cells following exposure to...

The ALDW classification for fetal insular morphology: gestational norms and screening utility

To observe the changes in fetal insular morphology with gestational age using the transverse thalamic view, and to preliminarily explore the value of this approach in cases with nervous system abnormalities. Pregnant women between 18 and 34 weeks of gestation who attended the Pek...

CSTF2 facilitates ATAD2 translation via m⁶A recognition to drive ER-positive breast cancer metabolic reprogramming and tumor progression

Abstract Objective Breast cancer (BC) is the most common malignancy among women worldwide, accounting for 11.7% of female cancer cases. Cleavage stimulation factor subunit 2 ( CSTF2 ), a key RNA-binding protein, modulates tumor development by influencing N⁶-methyladenosine (m⁶A)...

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1‐Mediated Cuproptosis, While Promoting M2 Macrophage Polarization

ABSTRACT This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin‐conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC). Based on the TCGA and GEPIA databases, t...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...