Ningbo University Affiliated Hospital

Delayed Diagnosis of Hereditary Transthyretin Cardiac Amyloidosis Presenting with Autonomic Neuropathy: A Case Report

Background: As a rare disease, cardiac amyloidosis (CA) has seen a deepening of epidemiological understanding, driven by advances in imaging and genetic testing, alongside drug development. However, the identification of suspected patients in the early stages remains inadequate....

Venetoclax plus azacitidine in younger adults with acute myeloid leukemia beyond historical comparisons. Comment on: "Venetoclax and azacitidine for younger acute myeloid leukemia patients independent of fitness for intensive chemotherapy"

Not available.

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

Machine learning clustering of multidimensional clinical features identifies four prognostically distinct sepsis subtypes

Sepsis is highly heterogeneous, and traditional “one-size-fits-all” treatment approaches are insufficient for optimal risk stratification. Using the MIMIC-III database, we employed unsupervised machine learning (k-means clustering) based on eight key clinical features (age, SOFA...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Threshold-dependent relationship between serum 25-hydroxyvitamin D₃ and α-tocopherol in children aged 0–11 years: a cross-sectional study

Abstract Cholecalciferol (Vitamin D₃) and α-tocopherol (Vitamin E) are lipophilic micronutrients that co-regulate key physiological processes in childhood, including immune function, antioxidant defense, and skeletal development. However, their interdependent dose-response relati...

Knockdown of VNN1 protects cardiac myoblasts from hypoxia/reoxygenation injury via the PI3K/Akt pathway

activating the PI3K/Akt pathway, highlighting VNN1 as a potential target for myocardial I/R injury.

Developing a health values framework for patients with cardiovascular-kidney-metabolic syndrome: a qualitative exploration through the lens of social determinants of health

Abstract Background Despite global calls for the advancement of patient-centered care, care planning often remains poorly aligned with patients’ lived social contexts and core values. This study aimed to understand what matters most to patients with cardiovascular-kidney-metaboli...

APOC1 deficiency disrupts M1/M2 macrophage balance via the ferroptosis and suppresses trophoblast invasion in recurrent pregnancy loss

The maternal–fetal interface requires tightly regulated immune homeostasis for successful pregnancy. Dysregulation of macrophage polarization and trophoblast invasion is implicated in recurrent pregnancy loss (RPL). However, the molecular mechanisms by which macrophage dysfunctio...

A comparative study of history of science, philosophy of science, and combined instruction on students’ understanding of the nature of science in a Chinese high school context

Despite the empirical evidence for the role of the history and philosophy of science in science education, the independent effects of history and philosophy of science courses have not been comparatively studied. Hence, this study implemented three elective courses—philosophy of...

Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial

Laser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myop...

RAD001-Adjuvanted Influenza Vaccine Synergizes With Anti–Programmed Cell Death Protein 1 Therapy to Enhance Antitumor Immunity in Programmed Cell Death Ligand 1–Low Murine Lung Cancer

Background: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have transformed lung cancer therapy, but their efficacy is often limited in tumors with low programmed cell death ligand 1 (PD-L1) expression and immunologically “cold” tumor microenvironme...

LncRNA DLGAP1-AS2 promotes ESCC progression and indicates unfavorable prognosis via the miR-101-3p/EZH2 axis

LncRNAs are crucial regulators and biomarkers in various cancers. However, their expression and functions in esophageal squamous cell carcinoma (ESCC) remain largely unexplored. This study explored the clinial relevance and mechanisms of LncRNA DLGAP1-AS2 in ESCC. Utilizing the G...

Phage vB_KpnM_NB cocktail synergizing with amikacin in inhibiting persister cells of Klebsiella pneumoniae

ABSTRACT The emergence of multidrug-resistant Klebsiella pneumoniae (KPN) and antibiotic-tolerant persister cells poses a significant challenge to existing anti-infection therapies. Given the urgent need for sustainable alternatives to antibiotics, phage cocktails are emerging as...

High immunosuppressants variability adversely affects post-transplant recurrence for patients with hepatocellular carcinoma

Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) is the most significant obstacle impacting the prognosis of patients. Managing the clinical application of immunosuppressive agents is difficult, owing to their limited therapeutic range and nota...

LINC01419–miR-132-3p–USP38 axis mediates high glucose-induced ferroptosis in vascular endothelial cells

Abstract Long non-coding RNA LINC01419 has been implicated in ferroptosis in various pathological conditions, yet its role in type 2 diabetes mellitus (T2DM) associated vascular endothelial dysfunction remains unclear. This study investigated the mechanism by which LINC01419 modu...

Trajectories of Kinesiophobia and Influencing Factors in Patients With Acute Myocardial Infarction

It is widely acknowledged that kinesiophobia is prevalent among patients suffering from acute myocardial infarction (AMI). Although heightened kinesiophobia significantly predicts adverse outcomes, it should be recognized that this fear is dynamic and typically evolves during the...

A comparative study of Kirschner wire intramedullary fixation versus bicortical fixation for metaphyseal-diaphyseal junction fractures of the pediatric distal radius

Abstract Background This study compared the clinical efficacy of closed reduction with Kirschner wire (K-wire) intramedullary fixation versus bicortical fixation for pediatric distal radius metaphyseal-diaphyseal junction (MDJ) fractures. Methods We retrospectively analyzed 61 ch...

Early-life high-dose omega-3 polyunsaturated fatty acid supplementation reduces risk of childhood asthma/wheezing: A meta-analysis of randomized controlled trials.

BACKGROUND AND OBJECTIVES: Asthma, a chronic inflammatory airway disease characterized by wheezing, imposes a substantial global health burden on children. Given the potential of early-life omega-3 polyunsaturated fatty acid (omega-3 PUFA) supplementation as an anti-inflammatory...