Ningbo No.6 Hospital

The relationship between functional prognosis in patients with infection after upper limb trauma: a predictive model based on HbA1c stratification and the mediating role of delayed rehabilitation

OBJECTIVE: To investigate the association between preoperative glycated hemoglobin (HbA1c) and upper limb function (Disabilities of the Arm, Shoulder and Hand [DASH] score) at 6 months post-surgery in patients with fracture-related infection (FRI) after upper limb trauma, and to...

Delayed Diagnosis of Hereditary Transthyretin Cardiac Amyloidosis Presenting with Autonomic Neuropathy: A Case Report

Background: As a rare disease, cardiac amyloidosis (CA) has seen a deepening of epidemiological understanding, driven by advances in imaging and genetic testing, alongside drug development. However, the identification of suspected patients in the early stages remains inadequate....

Research progress on emerging programmed cell death pathways in osteosarcoma therapy

Osteosarcoma is a prevalent malignant bone tumor in adolescents. For decades, clinical management has been hampered by two major challenges: chemoresistance and a high metastasis rate, resulting in persistently poor survival outcomes. Conventional therapies primarily focus on ind...

Oncolytic virus encoding decorin and the CD40 ligand boosts T-cell response and achieves a durable antitumor response during breast cancer treatment

Triple-negative breast cancer (TNBC) remains an aggressive disease with limited treatment options. Oncolytic adenoviruses represent a promising platform, but their efficacy as single agents is often insufficient. This study examined whether an oncolytic adenovirus co-delivering d...

TAMs-derived exosomal PD-L1 drives mitochondrial dysfunction and aberrant fatty acid oxidation via PGC-1α/PPARα axis to promote peritoneal metastasis in epithelial ovarian cancer

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the ovarian cancer peritoneal microenvironment; however, how their exosomes metabolically reprogram CD8⁺ T cells to induce dysfunction and promote peritoneal metastasis remains unclear. M2-type TAMs were in...

Threshold-dependent relationship between serum 25-hydroxyvitamin D₃ and α-tocopherol in children aged 0–11 years: a cross-sectional study

Abstract Cholecalciferol (Vitamin D₃) and α-tocopherol (Vitamin E) are lipophilic micronutrients that co-regulate key physiological processes in childhood, including immune function, antioxidant defense, and skeletal development. However, their interdependent dose-response relati...

Evaluation of bone fracture risk among men with prostate cancer treated with androgen receptor pathway inhibitor-containing therapies: a systematic review and meta-analysis

Androgen receptor pathway inhibitors (ARPIs) are widely used across multiple prostate cancer disease states, but fracture outcomes are inconsistently reported across randomized trials. We aimed to quantify the risks of all-grade and grade ≥ 3 trial-reported fracture-related adver...

A novel peptide interacts with RPL8 to alleviate portal hypertension by promoting ferroptosis

Liver fibrosis and mortal consequence of portal hypertension (PHT) is driven by hepatic stellate cells (HSCs) activation and their limited-explored property against elimination. We uncovered that HSC activation decreased the sensitivity to ferroptosis. By Ribo-seq, we identified...

Home-based digital exercise versus hospital physiotherapy for plantar fasciitis: a propensity-score-matched retrospective cohort study with dual-perspective cost-utility evaluation

OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of a 12-week home-based digital exercise programme with 12-week hospital-supervised physiotherapy for plantar fasciitis in routine Chinese tertiary-hospital care. DESIGN: Single-centre retrospective cohort st...

Effect of plate geometry on femoral nonunion treated with augmentative plating while retaining the intramedullary nail: a comparison of wavy and straight plates

Aseptic atrophic nonunion of the femoral shaft after intramedullary nailing is a common but difficult problem in orthopedic practice. Many surgeons turn to plate fixation with autogenous bone grafting because it can help both stabilize the bone and support healing. In this study,...

A clinico-radiomic nomogram for preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in early-stage cervical cancer

To develop and validate an integrated clinico-radiomic nomogram for the preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in patients with FIGO stage IB–IIA cervical cancer. A total of 200 patients who underwent radical hysterectomy were...

Identification of a three-gene prognostic signature associated with tumor immune characteristics in lung adenocarcinoma: A comprehensive analysis of multi-omics data

Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with substantial differences in clinical outcomes and therapeutic responses. However, robust molecular signatures integrating prognostic stratification with tumor biological and immune characteristics remain limited....

Accuracy of ultrasound in diagnosing anterior talofibular ligament injury: a meta-analysis

The anterior talofibular ligament (ATFL) is the most frequently injured structure of the ankle joint. This meta-analysis evaluates the diagnostic accuracy of ultrasound for anterior talofibular ligament injury. We systematically searched for PubMed, Embase, Web of Science, Scopus...

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

ABSTRACT Thymic epithelial tumors (TETs) are rare and heterogeneous malignancies whose aggressive epithelial states and microenvironmental organization remain poorly defined. Here, we integrated single‐cell RNA sequencing, spatial transcriptomics, multiplex immunofluorescence, bu...