Ningbo No. 2 Hospital

The relationship between functional prognosis in patients with infection after upper limb trauma: a predictive model based on HbA1c stratification and the mediating role of delayed rehabilitation

OBJECTIVE: To investigate the association between preoperative glycated hemoglobin (HbA1c) and upper limb function (Disabilities of the Arm, Shoulder and Hand [DASH] score) at 6 months post-surgery in patients with fracture-related infection (FRI) after upper limb trauma, and to...

15-PGDH inhibition in osteoarthritis: PGE2 skeletal interoception, cartilage regeneration and compartment-managed disease modification

Abstract Osteoarthritis is a whole-joint disease in which cartilage loss, synovial inflammation, subchondral bone remodelling and pain-related neural changes co-evolve, yet structural improvement does not reliably translate into pain relief. This Review centres prostaglandin E 2...

Imaging Manifestations and Clinical Analysis of 12 Cases of Anorectal Malignant Melanoma

AIM: To investigate the computed tomography (CT) and magnetic resonance imaging (MRI) features and clinical characteristics of primary anorectal malignant melanoma (ARMM).METHODS: This retrospective analysis was conducted on the clinical, imaging and pathological data of 12 patie...

Research progress on emerging programmed cell death pathways in osteosarcoma therapy

Osteosarcoma is a prevalent malignant bone tumor in adolescents. For decades, clinical management has been hampered by two major challenges: chemoresistance and a high metastasis rate, resulting in persistently poor survival outcomes. Conventional therapies primarily focus on ind...

Global spread and evolutionary trajectories of HIV-1 CRF01_AE: Insights from phylogenetic analysis

HIV-1 circulating recombinant form (CRF) 01_AE has driven major HIV epidemics across Southeast and East Asia for decades, yet the mechanisms underlying its long-term regional spread remain poorly resolved. Using near-complete genome sequences and Bayesian phylogeographic reconstr...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Standardized Spark-Pattern Cut-Mode Electrosurgical Bailout Workflow for Difficult Left Bundle Branch Area Pacing Lead Advancement: Procedural and Follow-Up Outcomes From a 15-Patient Case Series

BACKGROUND: Electrosurgical facilitation can aid difficult left bundle branch area pacing lead advancement, but standardized delivery patterns, reassessment logic, and follow-up lead performance remain insufficiently defined. METHODS: We retrospectively analyzed 15 consecutive pa...

Oncolytic virus encoding decorin and the CD40 ligand boosts T-cell response and achieves a durable antitumor response during breast cancer treatment

Triple-negative breast cancer (TNBC) remains an aggressive disease with limited treatment options. Oncolytic adenoviruses represent a promising platform, but their efficacy as single agents is often insufficient. This study examined whether an oncolytic adenovirus co-delivering d...

TAMs-derived exosomal PD-L1 drives mitochondrial dysfunction and aberrant fatty acid oxidation via PGC-1α/PPARα axis to promote peritoneal metastasis in epithelial ovarian cancer

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the ovarian cancer peritoneal microenvironment; however, how their exosomes metabolically reprogram CD8⁺ T cells to induce dysfunction and promote peritoneal metastasis remains unclear. M2-type TAMs were in...

Threshold-dependent relationship between serum 25-hydroxyvitamin D₃ and α-tocopherol in children aged 0–11 years: a cross-sectional study

Abstract Cholecalciferol (Vitamin D₃) and α-tocopherol (Vitamin E) are lipophilic micronutrients that co-regulate key physiological processes in childhood, including immune function, antioxidant defense, and skeletal development. However, their interdependent dose-response relati...

Early phosphate supplementation after newly detected hypophosphatemia in older ICU patients: a target trial emulation

Hypophosphatemia is common in critical illness, but whether initiating replacement promptly after a newly available low result improves clinical outcomes is uncertain. We used target trial emulation to estimate a per-protocol contrast in older intensive care unit (ICU) patients....

Identification of immune cell mitochondrial dysfunction characteristics and clinical predictive biomarkers in sepsis via multi-cohort machine learning and single-cell RNA sequencing

Sepsis involves dysregulated host responses with mitochondrial dysfunction as a key mechanism, yet its immune cell landscape and clinical utility are unclear. We integrated five GEO datasets (GSE65682, GSE95233, GSE54514, GSE26440, GSE26378) comprising 1,256 samples. Mitochondria...

Evaluation of bone fracture risk among men with prostate cancer treated with androgen receptor pathway inhibitor-containing therapies: a systematic review and meta-analysis

Androgen receptor pathway inhibitors (ARPIs) are widely used across multiple prostate cancer disease states, but fracture outcomes are inconsistently reported across randomized trials. We aimed to quantify the risks of all-grade and grade ≥ 3 trial-reported fracture-related adver...

An expert-level generalist AI for abdominal CT diagnosis

Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope. We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abd...

The bidirectional immunoregulatory effects of Traditional Chinese Medicine on the cGAS-STING signaling pathway and their translational prospects

The cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway is a central component of innate immunity, mediating host defense against pathogens, antitumor responses, and inflammation. Aberrant activation of this pathway is implicated in a spectrum of diseases,...

Weight regain following discontinuation of glucagon-like peptide-1 receptor agonists in adults who are overweight or obese: a systematic review and meta-analysis

Objective This study aims to explore the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on weight changes and the occurrence of adverse reactions in overweight or obese adults after drug withdrawal. Methods Computerized searches were conducted in evidence-based d...

Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial

Laser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myop...

Home-based digital exercise versus hospital physiotherapy for plantar fasciitis: a propensity-score-matched retrospective cohort study with dual-perspective cost-utility evaluation

OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of a 12-week home-based digital exercise programme with 12-week hospital-supervised physiotherapy for plantar fasciitis in routine Chinese tertiary-hospital care. DESIGN: Single-centre retrospective cohort st...

Effect of plate geometry on femoral nonunion treated with augmentative plating while retaining the intramedullary nail: a comparison of wavy and straight plates

Aseptic atrophic nonunion of the femoral shaft after intramedullary nailing is a common but difficult problem in orthopedic practice. Many surgeons turn to plate fixation with autogenous bone grafting because it can help both stabilize the bone and support healing. In this study,...

A clinico-radiomic nomogram for preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in early-stage cervical cancer

To develop and validate an integrated clinico-radiomic nomogram for the preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in patients with FIGO stage IB–IIA cervical cancer. A total of 200 patients who underwent radical hysterectomy were...