Ningbo No. 2 Hospital

A clinico-radiomic nomogram for preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in early-stage cervical cancer

To develop and validate an integrated clinico-radiomic nomogram for the preoperative prediction of guideline-defined indications for postoperative adjuvant therapy in patients with FIGO stage IB–IIA cervical cancer. A total of 200 patients who underwent radical hysterectomy were...

Identification of a three-gene prognostic signature associated with tumor immune characteristics in lung adenocarcinoma: A comprehensive analysis of multi-omics data

Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with substantial differences in clinical outcomes and therapeutic responses. However, robust molecular signatures integrating prognostic stratification with tumor biological and immune characteristics remain limited....

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

ABSTRACT Thymic epithelial tumors (TETs) are rare and heterogeneous malignancies whose aggressive epithelial states and microenvironmental organization remain poorly defined. Here, we integrated single‐cell RNA sequencing, spatial transcriptomics, multiplex immunofluorescence, bu...

Accuracy of ultrasound in diagnosing anterior talofibular ligament injury: a meta-analysis

The anterior talofibular ligament (ATFL) is the most frequently injured structure of the ankle joint. This meta-analysis evaluates the diagnostic accuracy of ultrasound for anterior talofibular ligament injury. We systematically searched for PubMed, Embase, Web of Science, Scopus...

Nicotinamide adenine dinucleotide phosphate hydrogen oxidase 2 exacerbates abdominal aortic aneurysm formation by inducing oxidative stress through autophagy inhibition.

, primary mouse vascular smooth muscle cells (VSMCs) were randomly divided into Control, AngII, AngII+GSK2795039, AngII+rapamycin (autophagy agonist, RA), and AngII+GSK2795039+RA groups. EDU assay, cell scratch assay, and mRFP-GFP-LC3 detection were conducted. ROS was measured by...