Ningbo Medical Center Lihuili Hospital

Expert Consensus on Robot-Assisted Vascularized Bone Grafting for the Treatment of Early-Stage Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) remains a progressive clinical challenge that predominantly affects young and active adults between 20 and 50 years of age. Without timely and effective surgical intervention, natural disease progression leads to structural subchondral fra...

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

Aberrant lipid metabolic reprogramming accelerates gastric cancer malignancy through diminished ceramide-driven ALPP inhibition

Metabolic reprogramming is a canonical hallmark of cancer that reflects the biological properties of tumors. Deciphering the metabolic profiles and key metabolites involved in tumor progression is pivotal for advancing metabolism-centric precision oncology against gastric cancer...

Association between the leuko-glycemic index and adverse outcomes in traumatic brain injury patients admitted to the intensive care unit: a cohort study from the MIMIC-IV database

Abstract Background Among the major global health burdens, traumatic brain injury (TBI) stands out as a significant source of death and long-term disability, characterized by intricate pathophysiological mechanisms. As an emerging inflammatory biomarker, the leuko-glycemic index...

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

Oncolytic virus encoding decorin and the CD40 ligand boosts T-cell response and achieves a durable antitumor response during breast cancer treatment

Triple-negative breast cancer (TNBC) remains an aggressive disease with limited treatment options. Oncolytic adenoviruses represent a promising platform, but their efficacy as single agents is often insufficient. This study examined whether an oncolytic adenovirus co-delivering d...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Prognostic value of dynamic changes in C‑reactive protein‑albumin ratio for patients with spontaneous intracerebral hemorrhage

Background To examine the predictive value of the C‑reactive protein‑albumin ratio (CAR) measured at distinct time points.Methods Multivariate logistic regression was applied to examine the links of CAR 1 (at admission), CAR 2 (7th day after admission), and ΔCAR (change between C...

Metabolism-guided precision oncology in hepatocellular carcinoma: vascular, stromal and immune crosstalk

Hepatocellular carcinoma (HCC) is characterized by extensive metabolic reprogramming, aberrant angiogenesis, immune evasion, and frequent resistance to systemic therapy. This review aims to synthesize current evidence on tumor-stroma-vascular metabolic crosstalk in HCC and to eva...

Association between ketogenic diet ratio and overactive bladder and nocturia among U.S. adults with hyperlipidemia: a multiple mediation analysis of metabolic, psychological, and frailty pathways

The ketogenic diet is a high-fat, low-carbohydrate diet. Its role in metabolic regulation has been widely studied. However, its metabolic impact in individuals with hyperlipidemia remains debated, with inconsistent evidence regarding lipid profiles, glycemic control, and inflamma...

RAD001-Adjuvanted Influenza Vaccine Synergizes With Anti–Programmed Cell Death Protein 1 Therapy to Enhance Antitumor Immunity in Programmed Cell Death Ligand 1–Low Murine Lung Cancer

Background: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have transformed lung cancer therapy, but their efficacy is often limited in tumors with low programmed cell death ligand 1 (PD-L1) expression and immunologically “cold” tumor microenvironme...

ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome

Background Social dysfunction is a core symptom of autism spectrum disorder (ASD), including fragile X syndrome (FXS), but its underlying neural circuits and molecular mechanisms remain poorly understood. Previous studies have implicated the amygdala and hippocampus in social beh...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...