Ningbo First Hospital

tRF-Gln-CTG-7 promotes AML cell growth and survival through AGGF1 and is associated with poor prognosis

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, characterized by marked biological heterogeneity and an unfavorable prognosis. tRNA-derived small RNAs (tsRNAs) are involved in tumor progression, but their roles in AML remain poorly understood, so we inve...

Realization of relaxed fabrication tolerances and on‑demand sensitivity in hybrid plasmonic‑photonic sensors

Hybrid plasmonic-photonic nanostructures hold significant promise for diverse applications spanning biosensing, environmental monitoring, pharmaceutical analysis, and optical devices. However, two core bottlenecks persist and impede their commercial use as sensors: the challenge...

ANTXR1 stabilizes DKK2 by preventing proteasomal degradation to drive EMT-like process and malignant progression in glioma

Glioma is the most prevalent and aggressive primary brain malignancy, characterized by a grim clinical prognosis. Although an epithelial–mesenchymal transition (EMT)-like process is implicated in driving glioma invasiveness, therapeutic resistance, and recurrence, the precise mol...

Coniferaldehyde Reverses PGK1–3-Phosphoglycerate–L-Serine Metabolic Reprogramming in Hindlimb Ischemia

Background/Objectives: Ischemic skeletal muscle undergoes metabolic remodeling that may influence vascular repair. We investigated whether coniferaldehyde (CA) regulates a phosphoglycerate kinase 1 (PGK1)–3-phosphoglycerate (3PG)–L-serine axis in mouse hindlimb ischemia (HLI). Me...

Machine learning clustering of multidimensional clinical features identifies four prognostically distinct sepsis subtypes

Sepsis is highly heterogeneous, and traditional “one-size-fits-all” treatment approaches are insufficient for optimal risk stratification. Using the MIMIC-III database, we employed unsupervised machine learning (k-means clustering) based on eight key clinical features (age, SOFA...

TAMs-derived exosomal PD-L1 drives mitochondrial dysfunction and aberrant fatty acid oxidation via PGC-1α/PPARα axis to promote peritoneal metastasis in epithelial ovarian cancer

Tumor-associated macrophages (TAMs) are the most abundant immune cells in the ovarian cancer peritoneal microenvironment; however, how their exosomes metabolically reprogram CD8⁺ T cells to induce dysfunction and promote peritoneal metastasis remains unclear. M2-type TAMs were in...

Developing a health values framework for patients with cardiovascular-kidney-metabolic syndrome: a qualitative exploration through the lens of social determinants of health

Abstract Background Despite global calls for the advancement of patient-centered care, care planning often remains poorly aligned with patients’ lived social contexts and core values. This study aimed to understand what matters most to patients with cardiovascular-kidney-metaboli...

APOC1 deficiency disrupts M1/M2 macrophage balance via the ferroptosis and suppresses trophoblast invasion in recurrent pregnancy loss

The maternal–fetal interface requires tightly regulated immune homeostasis for successful pregnancy. Dysregulation of macrophage polarization and trophoblast invasion is implicated in recurrent pregnancy loss (RPL). However, the molecular mechanisms by which macrophage dysfunctio...

Clinicopathologic analysis of multifocal myxopapillary ependymoma: report of 4 cases and literature review

Abstract Objective Myxopapillary ependymoma (MPE) stands as a rare variant of ependymoma, primarily found within the spinal cord and cauda equina regions. This article aims to delve into the clinical and pathological characteristics of multifocal myxopapillary ependymoma (MPE), s...

LncRNA DLGAP1-AS2 promotes ESCC progression and indicates unfavorable prognosis via the miR-101-3p/EZH2 axis

LncRNAs are crucial regulators and biomarkers in various cancers. However, their expression and functions in esophageal squamous cell carcinoma (ESCC) remain largely unexplored. This study explored the clinial relevance and mechanisms of LncRNA DLGAP1-AS2 in ESCC. Utilizing the G...

LINC01419–miR-132-3p–USP38 axis mediates high glucose-induced ferroptosis in vascular endothelial cells

Abstract Long non-coding RNA LINC01419 has been implicated in ferroptosis in various pathological conditions, yet its role in type 2 diabetes mellitus (T2DM) associated vascular endothelial dysfunction remains unclear. This study investigated the mechanism by which LINC01419 modu...

Identification of a three-gene prognostic signature associated with tumor immune characteristics in lung adenocarcinoma: A comprehensive analysis of multi-omics data

Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with substantial differences in clinical outcomes and therapeutic responses. However, robust molecular signatures integrating prognostic stratification with tumor biological and immune characteristics remain limited....

Potential mediating role of triglycerides in the nonlinear association between body roundness index and MASLD in nondiabetic adults

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, with visceral adiposity and dyslipidemia as key drivers. The body roundness index (BRI) is a novel anthropometric marker of visceral adiposity. Still, its nonlin...