Institution
Ninewells Hospital
Recent research
- BiologyOpen access
Cysteine-based molecular switches: a focus on KEAP1 and BACH1 in regulating the antioxidant response
Due to the chemical properties of their thiol groups and the surrounding amino acid environment, specific cysteines in proteins serve as the principal intracellular sensors for oxidants and electrophiles. In this review, we focus on the ubiquitin ligase substrate adaptor Kelch-li...
- Health & MedicineOpen access
Student and surgeon perceptions of a robotic theatre live-link within the undergraduate curriculum
Abstract Explore student and surgeon perceptions of robotic theatre live-links as part of an undergraduate medical degree programme. During the surgical block, in the fourth year of a five-year medical programme at the University of Dundee, a robotic live-link session was introdu...
- Health & MedicineOpen access
PURPOSE: Our retrospective study in 2025 found that the use of haemostatic agents in drainless outpatient parotidectomy (DLOP) is associated with an increased risk of seroma/sialoma formation and possible increase in infection risk. The aim of this study was to compare additional...
- Health & MedicineOpen access
Abstract The increasing prevalence of chronic liver diseases (CLDs) is a global health concern. CLDs can cause fibrosis, and there is an urgent need for antifibrotic agents. The primary driver of fibrogenesis, transforming growth factor beta 1 (TGF-β1), activates hepatic stellate...
- Health & Medicine
Abstract Purpose The medial collateral ligament (MCL) is the most commonly injured knee ligament, yet indications for reconstruction remain debated. Although consensus statements support allograft and hamstring autograft, comparative evidence regarding graft superiority is limite...
- BiologyOpen access
Abstract Background Rare diseases are a significant public health concern, with over 6,000 diseases identified with an estimated collective point prevalence of 5.6–6.9%. People living with rare disease face numerous challenges within healthcare including prolonged time to diagnos...
- AI & ComputingOpen access
Background: Gastroesophageal adenocarcinoma is predominantly a disease of older adults. However, older adults are underrepresented in randomised controlled trials (RCTs), and outcomes specific to this subgroup are underreported. Clinicians therefore extrapolate data from younger,...
- BiologyOpen access
The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment
Background and Purpose Opioids, such as morphine, are effective analgesics, but their persistent use is compromised by tolerance. In mice, tolerance is attenuated by β‐arrestin2 depletion or Src‐family kinase inhibitors, which may act through off‐target effects. We tested the eff...
- BiologyOpen access
Background: Glioblastoma is a primary aggressive brain tumor, with an average survival rate of ~14.6 months. The low therapeutic benefit of current treatments is in part due to glioblastoma-initiating cells hijacking microglia/macrophages to support tumor growth, prompting the de...
- BiologyOpen access
USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage
Abstract Proteolytic processing is a fundamental regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying such events are often poorly defined. Silencing Defective 2 (SDE2), an essential human protein, plays important roles in mRNA splicing...
- Health & MedicineOpen access
BackgroundAging causes declines in cognitive and motor functions, often manifested in altered gait. Dual-task gait is a sensitive marker for early functional changes. This study investigated whether neural network (NN) models can differentiate gait patterns across age groups unde...
- Health & Medicine
Anticoagulation and Antiplatelet Therapy in Chronic Subdural Hematoma: A Multicenter Evaluation
BACKGROUND AND OBJECTIVES: Chronic subdural hematomas (cSDH) are among the most common neurosurgical pathologies. Older adults also often have comorbidities treated with anticoagulant and antiplatelet (ACAP) medications. Managing clinicians frequently must weigh the benefits and...