Niigata University Medical and Dental Hospital

Metachronous hepatocellular carcinoma in a patient with Fontan physiology and type I congenital absence of the portal vein: repeat hepatectomy in the setting of dual abnormal hepatic hemodynamics: a case report

Fontan-associated liver disease is a recognized long-term consequence of the Fontan circulation and may progress to cirrhosis and hepatocellular carcinoma (HCC). Congenital absence of the portal vein (CAPV) is another rare vascular abnormality associated with hepatocellular nodul...

Allele-specific directionality and evolutionary timing of BRCA1/2 loss of heterozygosity in gastric cancer

Abstract Germline pathogenic variants in BRCA1 and BRCA2 are established cancer predisposition factors, but their biological role in gastric cancer remains poorly defined. We investigated whether BRCA1/2 -associated gastric cancers acquire loss of heterozygosity, which allele is...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Coarse-graining analysis for non-invasive, label-free, and quantitative evaluation of undulating motion in cultured oral mucosa epithelial cell sheets

Background Cultured oral mucosa epithelial cell sheets (COMECS) represent a promising therapeutic approach for epithelial repair, such as corneal reconstruction or esophageal mucosa defects; however, current quality assessment methods are largely invasive and destructive. Althoug...

Machine learning enables clinically feasible implementation of clot waveform analysis for differentiating causes of prolonged activated partial thromboplastin time

Abstract Activated partial thromboplastin time (APTT) is widely used as a coagulation screening test; nonetheless, its prolongation can result from diverse causes, complicating the diagnosis. Clot waveform analysis (CWA) has been proposed as a complementary method, although the c...