Niigata University

Epithelial integration in tissue-engineered oral mucosa using RGDTFI-presenting micropatterned collagen scaffolds

Objective To determine whether presentation of the integrin αvβ3/αvβ5-binding peptide motif RGDTFI on micropatterned collagen scaffolds improves epithelial coverage and stabilizes the epithelial–scaffold interface during fabrication of tissue-engineered oral mucosa (TEOM). Method...

Machine learning enables clinically feasible implementation of clot waveform analysis for differentiating causes of prolonged activated partial thromboplastin time

Abstract Activated partial thromboplastin time (APTT) is widely used as a coagulation screening test; nonetheless, its prolongation can result from diverse causes, complicating the diagnosis. Clot waveform analysis (CWA) has been proposed as a complementary method, although the c...

Real-world safety and effectiveness of olaparib maintenance after first-relapse platinum-sensitive ovarian cancer in Japan: a multicenter historical cohort (JGOG3026)

OBJECTIVE: The primary objective of the study was to evaluate the safety and effectiveness of olaparib maintenance therapy in Japanese patients with platinum-sensitive first-relapsed ovarian cancer. The secondary objective was to survey the treatment given after the olaparib main...

Induction of interleukin-6 by anti-ribosomal P protein immunoglobulin G3 autoantibody in monocytes through Fcγ receptor cross-linking

Kaho Sato, M.D., Hiroe Sato, M.D., Ph.D., Tomoya Watarai, M.D., Ayako Wakamatsu, M.D., Ph.D., Daisuke Kobayashi, M.D., Ph.D., Suguru Yamamoto, M.D., Ph.D., Yoshikatsu Kaneko, M.D., Ph.D.. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2026.0017

Brewing History: Technology Transfer, Institutional Inheritance, and Postcolonial Reinterpretation in Taiwan’s Sake Industry

Although Taiwan’s sake industry remains a small market niche, it represents a historically significant colonial and postcolonial industrial formation. Drawing on historical literature, this study traces its development across a century, from the early Japanese colonial period to...