Niigata University

Topological data analysis of China’s stock market risks to detect early warning signals

This study examines the behaviour of the Shanghai and Shenzhen stock exchanges during the 2015 China stock market crash and the 2020 COVID-19 pandemic. Using topological data analysis (TDA), we investigate whether topological indicators extracted from the Shanghai–Hong Kong (SHHK...

Radiative Corrections and Reheating in Supergravity Models of Inflation

We consider the effects of radiative corrections in Starobinsky-like models of inflation, concentrating on models of inflation formulated in N=1 no-scale supergravity. Inflaton couplings with matter fields are necessary for reheating and these have an impact on loop corrections d...

Peak ground acceleration underestimates narrow-band seismic amplification on mountain slopes

Abstract Topographic amplification is widely invoked to explain strong shaking and slope failure in mountainous terrain, yet direct field observations remain limited. Here we analyze 24 regional earthquakes recorded by a four-station strong-motion array spanning a ridge crest, a...

A High-Density Supercritical Fluid of H2

Abstract This study aimed to elucidate the structural evolution of supercritical fluid hydrogen (SCF H2) under high pressure. X-ray diffraction was performed on SCF H2 using synchrotron radiation at room temperature. The structure factor S(Q) was observed in a low-Q region at eac...

Sexual segregation in foraging behavior varies with breeding site and year in seabirds

Abstract In many animals, behavioral sex differences can produce spatial or temporal segregation, known as sexual segregation, which is thought to reduce competition and satisfy sex-specific physiological demands. In breeding central-place foraging seabirds, sexual segregation ma...

Low Energy Bipolar Radiofrequency Ablation Combined With a Needle Electrode Connected in a Parallel Electrical Circuit to Create an Isolated Intramyocardial Lesion

ABSTRACT Background An ideal ablation method to create lesions inside the thick myocardium has not been well established. This experimental study was performed to assess whether low energy bipolar (BIP) radiofrequency (RF) ablation combined with a needle electrode can create an i...

Rapid genome-wide purging following tsunami-induced hybridization in a stickleback population

Speciation is the process by which barriers to gene flow evolve between populations. As speciation approaches completion, genome-wide divergence can be maintained in the face of hybridization. Because real-time observations of genomic changes following hybridization in natural po...

Association Between Social Networking Service Use at Age 76 and Six-Year Frailty Trajectories in Community-Dwelling Older Adults

Background: Frailty prevention is a critical public health priority in Japan’s rapidly aging society. Although the use of social networking services (SNSs) has increased, longitudinal evidence regarding its association with frailty remains limited. Methods: This population-based...

Metachronous hepatocellular carcinoma in a patient with Fontan physiology and type I congenital absence of the portal vein: repeat hepatectomy in the setting of dual abnormal hepatic hemodynamics: a case report

Fontan-associated liver disease is a recognized long-term consequence of the Fontan circulation and may progress to cirrhosis and hepatocellular carcinoma (HCC). Congenital absence of the portal vein (CAPV) is another rare vascular abnormality associated with hepatocellular nodul...

Multiplex LAMP-LFA for rapid field-compatible detection of environmental DNA from Schistosoma japonicum and Oncomelania hupensis quadrasi

Abstract This study developed a field-adaptable multiplex Loop-Mediated Isothermal Amplification combined with Lateral Flow Assay (mLAMP-LFA) for simultaneous detection of Schistosoma japonicum and its intermediate host, Oncomelania hupensis quadrasi , in freshwater environments...

Rare WDR19 Variants in Patients With Dental and Retinal Anomalies

Genetic variants in WDR19 cause ciliopathies with craniofacial and ectodermal features, including dental and retinal anomalies. This study characterized the clinical and molecular features of patients with isolated dental anomalies harboring WDR19 variants. Clinical and radiograp...

Allele-specific directionality and evolutionary timing of BRCA1/2 loss of heterozygosity in gastric cancer

Abstract Germline pathogenic variants in BRCA1 and BRCA2 are established cancer predisposition factors, but their biological role in gastric cancer remains poorly defined. We investigated whether BRCA1/2 -associated gastric cancers acquire loss of heterozygosity, which allele is...

Shall we score? The SHALL-WE score for optimizing sclerotherapy in superficial lymphatic malformations

No standardized tool guides the decision of when to escalate beyond sclerotherapy in lymphatic malformations (LMs). We developed the SHALL-WE score (Severity, Histology, And Location—Lymphatic malformation: When to Escalate) to define the optimal sclerotherapy threshold in superf...

Orthodontic and surgical treatment patterns in hemifacial microsomia: a retrospective multi-institutional study in Japan

Hemifacial microsomia is a congenital craniofacial condition characterized by variable facial asymmetry and mandibular hypoplasia. Its management often requires long-term multidisciplinary care, including orthodontic and surgical treatment. However, multi-institutional data on tr...

Support for Disclosure of Hereditary Tumor Risk to Children and Adolescents: A Scoping Review

ABSTRACT Aim This study aimed to map evidence on disclosure support for communicating hereditary tumor‐related information to children and adolescents and identify evidence gaps. Methods This scoping review was conducted in accordance with the Joanna Briggs Institute methodology...

Genetic Characterization of MAPT Exon 6 Variants in Indonesian Patients with Vascular Dementia: A Cross-Sectional Sequencing Study

Background The microtubule-associated protein tau (MAPT) gene plays a critical role in neuronal microtubule stabilization and has been widely implicated in neurodegenerative disorders, including vascular dementia. However, the molecular characterization of MAPT gene variants in p...

Black-hole formation and thermalization in open JT gravity

A bstract Black-hole formation is expected, via holography, to correspond to thermalization in the boundary theory. For open quantum systems, an initial pure state generically evolves into a mixed state irreversibly, suggesting that horizon formation in the bulk should arise. In...

Structural origin of the strong effect of attraction on bulk viscosity in simple liquids

The effects of pairwise attraction and three-body interactions (Axilrod-Teller-Muto triple-dipole potential) on bulk viscosity, compared with shear viscosity, were investigated using molecular dynamics simulations, with particular focus on the underlying structural dynamics. Our...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Coarse-graining analysis for non-invasive, label-free, and quantitative evaluation of undulating motion in cultured oral mucosa epithelial cell sheets

Background Cultured oral mucosa epithelial cell sheets (COMECS) represent a promising therapeutic approach for epithelial repair, such as corneal reconstruction or esophageal mucosa defects; however, current quality assessment methods are largely invasive and destructive. Althoug...