NIHR Surgical Reconstruction and Microbiology Research Centre

Primary diffuse leptomeningeal melanomatosis presenting as chronic meningitis and dense spinal plaques

Primary diffuse leptomeningeal melanomatosis (PDLM) is an exceptionally rare and aggressive central nervous system melanocytic tumour, often masquerading as inflammatory or infective leptomeningeal disease. A woman in her early 60s presented with hydrocephalus and diffuse leptome...

Comparative effects of glucagon-like peptide-1-based regimens on peripheral arterial and limb events in type 2 diabetes: a network meta-analysis of randomized trials

Peripheral artery disease (PAD) is a disabling condition in patients with type 2 diabetes mellitus (T2DM), yet lower-extremity outcomes are rarely prespecified in trials of GLP-1-based therapies. We compared individual GLP-1-based regimens for PAD-related vascular and limb events...