NIHR Newcastle Biomedical Research Centre

Front-line decision-making: a thematic analysis of interviews with hospital staff on referrals, admissions, and care for people with multiple long-term conditions

BACKGROUND: Multiple long-term conditions (MLTC) are increasingly common and present challenges for hospital healthcare professionals (HCPs) making decisions about admissions, referrals, and care management in the context of a single-organ oriented health system. This qualitative...

‘People need to be a bit more understanding that my body is wrecked’: A qualitative exploration of inpatient hospital care for people living with multiple long-term conditions

BACKGROUND: Living with multiple long-term conditions (MLTC) is becoming increasingly common with far-reaching consequences for individuals and healthcare systems. People with MLTC often face complex care pathways through health systems - especially hospitals, which are largely c...

Mapping equity-relevant inputs of AI mental health tools to routine primary care data: a population-based study of 7.19 million adults with multiple long-term conditions in England

Abstract Background Artificial intelligence-enabled tools are increasingly used to support mental health diagnosis, triage and clinical decision-making. However, limited evidence exists on whether these tools incorporate equity-relevant population characteristics, particularly am...

Deep phenotyping of white matter tissue composition in dementia with Lewy bodies

Abstract Background White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue C...

Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks...

A qualitative exploration of information access and provision for cancer survivors experiencing chronic bowel symptoms after pelvic radiotherapy: informing a framework to guide improvements to information provision

Abstract Purpose For people living with and beyond cancer, access to clear, accurate, relevant information is crucial for meaningful participation in shared decision-making and is associated with better quality-of-life. Many cancer patients who undergo pelvic radiation experience...

Effect of diet on cognition, mental health and wellbeing among adolescents: a systematic review

A healthy diet is crucial for adolescents’ health and wellbeing. Current literature on dietary intake and its association with cognition, mental health and wellbeing has mainly focused on younger children. The aim of this systematic review was to explore the evidence for these as...

Understanding the impact of Multiple Long-Term Conditions (MLTC) on the completion of delirium screening documentation: analysis using routinely collected clinical data

Abstract Introduction Multiple Long-Term Conditions (MLTC) are a recognised risk factor for delirium, but little is known about the impact of MLTC on delirium screening. This study aimed to explore the impact of MLTC on delirium screening documentation for older, hospitalised peo...

Development and evaluation of a dental nurse-led acupuncture service for myogenous temporomandibular disorder

Aims Acupuncture is an established treatment for myogenous temporomandibular disorder (mTMD). Long waiting times and limited outcome recording highlighted service improvement need. A dental nurse-led acupuncture clinic was introduced to increase access and improve clinical outcom...

Interaction of walking activity and long-term air pollution on exacerbation rate in COPD

Background Regular walking activity can improve the prognosis in people with chronic obstructive pulmonary disease (COPD). However, its benefit may be reduced when living in highly polluted areas. Aim To assess the combined effects of walking activity and air pollution on the rat...

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

Can discussions with patients and the public clarify missing data mechanisms for digital outcome measures?

Abstract Background Analysis of clinical trials with missing data requires statistical assumptions. When novel digital outcome measures are used, it is particularly important to understand trial participants’ experiences with the device. This can illuminate the reasons for and sp...

From questions to impact in spinal muscular atrophy - identifying community-driven research priorities through a multi-stakeholder European initiative

Abstract Background Advances in medicines have transformed the outlook for people living with spinal muscular atrophy (SMA), yet many needs remain unmet. As the scientific and clinical environment evolves, aligning research priorities with the lived experience of patients is incr...

Digenic disease causing variants in a patient with severe nephrocalcinosis

Abstract Background Nephrocalcinosis and cystinuria are two distinct kidney disorders. Nephrocalcinosis is the abnormal, generalised deposition of calcium salts, primarily calcium phosphate or calcium oxalate, within the kidney's parenchyma, and has multiple causes including meta...

What works, for whom, and under what circumstances for recipients of training in opportunistic behaviour change conversations: A mixed methods realist evaluation protocol

Abstract Background ‘Making Every Contact Count’ (MECC) is a person-centred initiative that enables service providers across settings to support behaviour change through conversations about health and wellbeing. MECC has been widely implemented across the UK and internationally,...

Affected others’ perspectives on the burden, drivers, and prevention of gambling-related harms: a qualitative study

Abstract Background Gambling is increasingly recognised as a public health concern, with harms extending beyond individuals who gamble to families and communities. However, young people and adults affected by others’ gambling remain under-represented in research on harm preventio...