NIHR Manchester Biomedical Research Centre

Within‐Sector Job Mobility and Worker Outcomes in England's Adult Social Care Sector

ABSTRACT England's adult social care sector faces persistently high staff turnover. This article examines the effects of individual‐level within‐sector job mobility on hourly pay and working hours and identifies the employer types and contractual arrangements that attract such mo...

Diagnostic Yield of Sequencing in Prenatal Agenesis of the Corpus Callosum in a Well‐Phenotyped International Cohort

ABSTRACT Objective To evaluate the incremental diagnostic yield of sequencing in a large, well‐phenotyped international cohort of fetuses with prenatally diagnosed agenesis of the corpus callosum (ACC) and to identify associated genes and variants. Methods Retrospective multicent...

How is ‘culture’ made relevant in consultations between General Practitioners and ethnic minority patients?: a conversation analysis

Abstract Background General Practitioners (GPs)—usually the first points of healthcare in the UK—are required to provide ‘whole person care,’ by considering patients’ cultural backgrounds. Previous research suggests that doctors’ interactional behaviour can contribute to ethnic h...

Outcomes in JIA have greatly improved, but we can still do better

Abstract Outcomes for children and adolescents with juvenile idiopathic arthritis (JIA) have improved substantially over the past two decades, driven by biologic and targeted synthetic DMARDs, treat-to-target strategies with regular standardized assessments, and multidisciplinary...

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

OBJECTIVE: To identify the specific gastrointestinal (GI) symptoms associated with clinically relevant fatigue in systemic sclerosis (SSc), beyond the established association between overall GI involvement and fatigue. METHODS: We conducted a cross-sectional study including conse...

DIALOR (DIgitAL cOaching for fRailty): a feasibility and acceptability study of a digital health coaching intervention for older people with frailty in primary care

Abstract Purpose To assess the acceptability and feasibility of a digital health platform for long-term disease management combined with health coaching for people living with mild-moderate frailty in Southwest England. Methods Older adults (65 years+) with frailty (using electro...

The diagnosis and management of primary mediastinal B‐cell lymphoma: A British Society for Haematology guideline

Summary Primary mediastinal B‐cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B‐cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematolog...

Modelling Tetralogy of Fallot: insights and limitations of animal models

Tetralogy of Fallot (TOF) is the commonest cyanotic congenital heart disease, arising from antero-cephalad deviation of the outlet septum during outflow tract (OFT) morphogenesis, producing a ventricular septal defect, overriding aorta, pulmonary stenosis, and right ventricular h...

Implementation of minimum unit pricing for alcohol in Scotland and subsequent rates of hospital-admitted self-harm: controlled interrupted time series analysis

BACKGROUND: Harmful alcohol use is a major modifiable risk factor for self-harm. We aimed to examine associations between minimum unit pricing for alcohol, introduced in Scotland in 2018, and rates of hospital-admitted self-harm. METHODS: Data were obtained from Public Health Sco...