NIHR Exeter Clinical Research Facility

Reported outcomes for patients following postoperative periprosthetic femoral fractures

Aims: Postoperative periprosthetic femoral fracture (POPFF) is an increasingly common and morbid complication of arthroplasty. This review aims to determine what outcomes are reported for POPFF and how they are measured, to inform the development of a core outcome set. Methods: S...

Association between Glycemic Control and Survival in Patients with Type 2 Diabetes on Peritoneal Dialysis

Background: Diabetes is the leading cause of kidney failure globally affecting 40% of people receiving peritoneal dialysis (PD). High quality data on the potential impact of improving glycemic control is needed to inform the current recommendations to individualise HbA 1C targets...

Demonstration of how group model building can be used to understand barriers and facilitators to “at-risk” young people’s access to community assets for mental health support: a participatory study

Abstract Background Community assets (e.g. green spaces, youth centres) can support the mental health of young people. However, less is known about barriers and facilitators to access these assets. This manuscript aims to demonstrate how group model building – a participatory res...

Clinical Utility of a Type 1 Diabetes Genetic Risk Score Measured as Part of MODY Genetic Testing

<p dir="ltr">Objective</p><p dir="ltr">To evaluate the clinical utility of incorporating a type 1 diabetes genetic risk score (T1DGRS) into monogenic diabetes gene panel testing for individuals referred with suspected maturity-onset diabetes of the young (MODY)...

Modulators of epithelial-mesenchymal transitions in prostate cancer: potential for novel therapeutics development

Abstract Research in the area of hallmarks of cancer has opened the possibility of designing novel therapeutic interventions based on modulating cancer properties. Interestingly, the epithelial-mesenchymal transition (EMT), important in both tumour growth and metastasis, has not...

Clinical efficacy to climate accountability

There is increasing global recognition of the importance of sustainability in the design and delivery of healthcare, including trauma and orthopaedics. There has, however, to date been little focus on providing high-quality research which includes environmental outcomes to guide...