NIHR Bristol Biomedical Research Centre

Genetic risk factors for postoperative complications after major surgery and shared genetic aetiology with non-postoperative phenotypes

Abstract Background Up to 15% of patients worldwide experience serious postoperative complications after major surgery. We explored the genetic basis of five common postoperative complications and whether they share genetic aetiology with their non-postoperative equivalents. Meth...

Impact of the HPV vaccination programme on anal HPV infection in gay, bisexual and other men who have sex with men: multi-site enhanced surveillance study in specialist sexual health services in England

ABSTRACT Background A national human papillomavirus (HPV) vaccination programme for gay, bisexual, and other men who have sex with men (GBMSM) in England began in 2016. We evaluated the impact of this programme by monitoring the prevalence of type-specific HPV infections over tim...

A qualitative exploration of further education college staff perspectives on the challenges and opportunities for using physical activity to support student mental health in England

Abstract Background The increasing prevalence of poor mental health amongst young people is a public health concern, and physical activity (PA) is a potential intervention that has both physical and mental health benefits. While education settings are important contexts for inter...

Demonstration of how group model building can be used to understand barriers and facilitators to “at-risk” young people’s access to community assets for mental health support: a participatory study

Abstract Background Community assets (e.g. green spaces, youth centres) can support the mental health of young people. However, less is known about barriers and facilitators to access these assets. This manuscript aims to demonstrate how group model building – a participatory res...

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...

Teachers’ perceptions of physical activity in children and young people with type 1 diabetes: a qualitative systematic review protocol

Abstract Background Type 1 diabetes is a lifelong condition usually diagnosed in childhood. It requires daily management to control blood glucose and avoid complications. Physical activity brings important physical and emotional benefits, but children with the condition are often...

Effects of maternal and paternal smoking on offspring cardiometabolic risk factors in adulthood: a multi-method intergenerational Mendelian randomization study

Abstract Background Parental smoking has been linked to several adverse offspring cardiometabolic outcomes; however, evidence is conflicting regarding the causal and long-term nature of these associations. Methods We investigated the effects of maternal and paternal smoking, capt...

Glucagon-like peptide-1 receptor agonists are associated with improved 90-day outcomes after total hip and knee arthroplasty

Aims Obesity and diabetes are risk factors for developing osteoarthritis and associated with worse outcomes following total hip (THA) and total knee arthroplasty (TKA). Glucagon-like peptide-1 receptor agonists (GLP-1as) improve glycaemic control and promote weight loss. The aim...