Newcastle Hospitals - Campus for Ageing and Vitality

Evaluating the Interaction of Alzheimer Biomarker Burden and α-Synuclein Status on Cognitive Trajectories in Parkinson Disease: Methodological Challenges and Power Estimates

Background: Alzheimer disease (AD) and α-synuclein copathology frequently co-occur in Parkinson disease (PD), but whether their interaction accelerates longitudinal cognitive decline is unknown. Objective: To investigate whether the cross-sectional interaction between AD biomarke...

Low-Carbohydrate Diets, Nutritional Adequacy, Glycemia, and Perinatal Outcomes in Women With Gestational Diabetes Mellitus: A Secondary Analysis of the DiGest Trial

OBJECTIVE The optimal dietary carbohydrate intake for pregnant women is disputed internationally. Many authorities recommend a minimum of 175 g/day of carbohydrates primarily to support maternal brain glucose requirements and normal fetal brain development. We assessed whether lo...

Deep phenotyping of white matter tissue composition in dementia with Lewy bodies

Abstract Background White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue C...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...