New York State College of Veterinary Medicine

Alzheimer’s disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of...

Infection and transmission dynamics of bovine and human influenza A H5N1 viruses in mouse and hamster models

ABSTRACT Here we investigated the pathogenesis and contact transmission of bovine- and human-derived highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b genotype B3.13 viruses in mammalian models. Using reverse genetics, we rescued three naturally occurring viruses, rTX2...

A homozygous hypomorphic FBN1 splice region variant in domestic cats with Marfan syndrome

Marfan syndrome (MFS) is an autosomal dominant connective tissue disease caused by variants in the fibrillin 1 ( FBN1 ) gene. While common in humans, spontaneous animal models are rarely reported. We present the first phenotypic and molecular characterization of MFS in domestic c...

Establishment of Patient-Derived Xenotransplant and Cell Line Models for Canine B-Cell Lymphoma

High-grade canine B-cell lymphoma (cBCL) is a spontaneous cancer in dogs with similar pathologic features as human diffuse large B-cell lymphoma (DLBCL). The value of comparative oncology to both dogs and humans has long been recognized, but the progress in cBCL research has been...

Epidural 0.125% ropivacaine is safe but insufficient for induced tibiotarsal joint pain

Abstract Background Epidural injection of a low concentration of the local anaesthetic ropivacaine produces analgesia without neurological deficits or ileus in people. Objective To determine if epidural 0.125% ropivacaine mitigates induced hindlimb lameness in horses while preser...

Antibody kinetics against tetanus toxoid before and after primary vaccination of foals

Abstract Background Vaccination recommendations for foals against Clostridium tetani vary. Available studies assessing foal immune responses, maternal antibody interference, or individual variation often used small foal numbers. Objectives To quantify antibody responses after tet...

Comparison of Plasma Protein Fractions and Electrophoretograms in Non‐Laying and Egg‐Laying Domestic Chickens

BACKGROUND: Protein electrophoresis (EPH) is a valuable diagnostic tool in veterinary medicine, particularly in non-mammalian species where albumin measurement has historically been considered inaccurate by routine biochemistry analyzers. Physiologic processes such as egg-laying...