New York Psychoanalytic Society and Institute

Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons

The association of cues with the absence or presence of danger is crucial to survival. The synaptic changes that enable association with the absence of danger are unknown, but a role for the tail of the striatum (TS) has been implicated. To investigate this, we conditioned mice t...

Family mass murder in the United States, 1970–2019: Perpetrator mental health characteristics and the role of domestic violence

Abstract Examining perpetrator characteristics of, and risk factors for, different types of mass murder, such as family mass murder—the most common type—could have important ramifications for preventive efforts. Histories of domestic violence and mental illness are of particular...

HIV Testing and Care Among Publicly Insured Enrollees With Schizophrenia: Is There a Benefit to Dual Eligibility?

Background Patients with schizophrenia experience gaps in the human immunodeficiency virus (HIV) care continuum. We examined the impact of dual enrollment in Medicare upon HIV testing and retention among Medicaid‐enrolled patients with schizophrenia. Methods Using Medicaid Analyt...

Intervention Design for Individual Behavior Change in Stroke Prevention Trials

Stroke prevention requires that patients follow recommended health behaviors. However, few stroke behavioral interventions have been shown to produce clinically significant behavior change in clinical trials, likely thwarted in the design process by limited application of behavio...

Harnessing biological variability for mechanistic inference: A stochastic framework applied to neural stem cell dynamics

Inter-individual heterogeneity is often treated as noise, yet its temporal evolution can reveal regulatory mechanisms hidden from mean-field behavior. We present a stochastic framework that exploits variability for mechanistic inference in cell population dynamics. Using adult ne...

Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition

ABSTRACT Schizophrenia is associated with profound working memory deficits, for which there are no approved treatments. Rare heterozygous null mutations in SETD1A , a gene encoding a key epigenetic regulatory protein, have been definitively linked to increased risk for schizophre...