New Jersey Institute of Technology

Per- and Polyfluoroalkyl Substances (PFAS) Cytotoxicity and Genotoxicity in HepG2 Human Hepatoma Cells

Abstract Per- and polyfluoroalkyl substances (PFASs) commonly occur as complex mixtures, yet the relationships among PFAS structure, cytotoxicity, and DNA strand-break responses remain incompletely resolved. We evaluated 11 PFASs selected to span environmentally prevalent and reg...

CfDNA methylation profiling in blood following moderate-to-severe traumatic brain injury using brain cell type–enriched signatures: A pilot study

The human brain consists of diverse cell types that collaboratively perform complex functions and form intricate neuronal networks. When traumatic brain injury (TBI) occurs, multiple molecular pathways involving diverse cell types are activated in response to injury. Understandin...

Efficiency of Estimating Smooth Functions of Parameters in Rare-Event Contexts

Consider an estimand that is a known smooth function of an unknown vector of parameters, such as means, probabilities, quantiles, etc. Some but not necessarily all of the parameters relate to rare events, which typically make them difficult to estimate with naive Monte Carlo, so...

Distortion-Constrained Minimax Data Sanitization with Multiple Adversaries

We study a privacy-preserving data-sharing setting where a privatizer transforms private data into a sanitized release observed by an authorized reconstructor and two unauthorized adversaries, each with access to side information correlated with the private data. An adversary is...

Bootstrap Nonparametric Inference Under Data Integration

ABSTRACT We propose multiplier bootstrap procedures for nonparametric inference and uncertainty quantification of the target mean function, based on a framework of integrating target and source data under a covariate shift scenario with equal target and source mean functions. We...

Compressor-Aware Feature Analysis and Learning-Based Performance Prediction for Scientific Data Compression

High-fidelity scientific instruments and simulations are producing data at unprecedented volumes and rates, imposing substantial pressure on storage, transmission, and analysis. In order to alleviate the challenges brought to highperformance computing I/O and storage, compression...

Macrocyclic ligands as corrosion inhibitors: Macrocyclic effects, host-guest chemistry, coordination and complexation with metal surfaces and ions

The increasing demand for durable and efficient corrosion inhibitors has intensified interest in macrocyclic ligands as an emerging class of tunable corrosion inhibitors. Several salient features, including macrocyclic effect, host-guest recognition, preorganized multidentate coo...

Dosing and delivery of bacteriophage therapy in a murine wound infection model

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant Pseudomonas aeruginosa. However, dosing and delivery strategies for phage therapy remain underdeveloped. In a mouse wo...

Aging-Induced Additive Release and Degradation Mechanisms in Recycled Polyvinyl Chloride: Coupling Experimental and Molecular Dynamics Insights

Abstract The global accumulation of plastic waste has driven the widespread adoption of recycling strategies for sustainable resource management. However, uncertainties in recycled material quality and the release of plastic additives remain critical challenges for environmental...

Toward a Polyvocal Semantic Infrastructure for Tabletop Role-Playing Game Research: A Scoping Review of Multimedia Play Data

Tabletop role-playing game (TTRPG) research increasingly produces complex multimodal and multimedia evidence, including speech, audiovisual recordings, character sheets, maps, platform traces, session notes, game-state data, and retrospective documentation. However, the field lac...

Mitigating artificial intelligence-related animal welfare risks in animal farming

In animal farming, artificial intelligence (AI) is increasingly promoted as a means to enhance productivity, reduce greenhouse gas emissions, and improve animal welfare. However, discussion of the animal welfare risks arising from these technologies, particularly emerging generat...

Training-free ranking from pairwise comparisons via acyclic graph construction

Abstract Ranking from weighted pairwise comparisons asks for a global order that respects observed preferences as well as possible. We study a training-free, deterministic pipeline that builds an acyclic backbone on the comparison digraph using an MWFAS-inspired local-ratio heuri...

Well-connected community detection at extreme scale: shared- and distributed-memory parallel algorithms

Abstract Community detection algorithms such as Leiden frequently produce clusters thatare internally disconnected or poorly connected, limiting their utility indownstream network analysis. The Well-Connected Clusters (WCC) and ConnectivityModifier (CM) algorithms address this by...

Behind the hype: a closer look at voice assistant skills, product control strategy and user evaluations

Purpose Drawing on the assemblage framework and signaling theory, this research examines how a voice skill's product control strategy, specifically controllability variety and complexity, shapes perceived intelligence and user evaluations. It also explores the invocation strategy...

Large deviations of piecewise-deterministic Markov processes with application to stochastic calcium waves

Abstract We prove a large deviation principle for piecewise deterministic Markov processes (PDMPs). This is an asymptotic estimate for the probability of a trajectory in the large size limit. Explicit Euler–Lagrange equations are determined for computing optimal first-hitting-tim...

The origin of dark lane on sunspot’s light bridge

Light bridges (LBs), embedded in sunspots, appear as elongated narrow bright features, in contrast to the surrounding dark sunspot umbra or penumbra. Under high-resolution observations, dark lanes were reported along the spine of LBs. Although numerical modeling explains the basi...

Molecular Modelingof Triethyl Phosphate: Extensionand Validation of the TraPPE Force Field

Abstract The study of physical properties of organophosphorus chemical warfare agents (CWAs) is essential for detection, protection, decontamination, and destruction. Due to the extreme toxicity of CWAs, other organophosphorus molecules with similar chemical structures are employ...