Netherlands Pharmacovigilance Centre Lareb

Safety and Effectiveness of Inebilizumab in Patients with Neuromyelitis Optica Spectrum Disorder: Interim Analysis of a Post-marketing Surveillance in Japan

Inebilizumab is used in Japan for relapse prevention in aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Nationwide post-marketing surveillance (PMS) is underway to evaluate the real-world safety and effectiveness of inebilizumab in Japanese pa...

Population cycles and hydroclimatic forcing in a wetland oak population: A 1.800-year tree-ring record from the Rhine Delta

Subfossil bog oaks provide high-resolution archives of hydroecological variability in fluvial wetlands. In this study we analyse an exceptionally large dendrochronological dataset of 500 oak trunks recovered from peat deposits in the Angstel–Vecht region of the western Netherland...