Netherlands Metabolomics Centre

Maternal SARS-CoV-2 exposure and neonatal metabolic maturation during the first month of life: a longitudinal urinary metabolomics study

Abstract The first month of life is characterized by rapid metabolic adaptation as neonates transition from intrauterine to extrauterine life. Whether maternal SARS-CoV-2 infection influences these developmental trajectories remains largely unexplored. In this longitudinal study,...

Deep3DCCS: Geometry-Driven Collision Cross Section Prediction from Multi-View Molecular Projection Tensors

Abstract Collision cross section (CCS) measurements from ion mobility–mass spectrometry improve confidence in molecular identification in metabolomics and lipidomics and reduce false-positive annotations in untargeted analyses. However, experimental CCS coverage remains incomplet...

DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1

Abstract Approximately 60% of the tumour suppressor protein BRCA1 is encoded by a single exon. Many tumours carry mutations in this exon, often resulting in exon skipping and thus a protein of a severely reduced size. Although none of the well-described protein domains of BRCA1 a...

Modulating pressure in the Orbitrap improves sensitivity and mass resolution in charge detection mass spectrometry

Abstract Native mass spectrometry has become a key method for studying macromolecular assemblies, providing insights into structures, stoichiometries, and binding interactions. A key aspect for the transmission of electrospray-generated bioparticles into the mass analyzer is the...