Nepean Hospital

Paediatricians' Support for Adolescent Vaping Cessation in Australia: A National Cross‐Sectional Study

ABSTRACT Background Adolescent vaping is rising globally and in Australia, and evidence on paediatricians' cessation support is scarce. This study examined predictors of paediatricians' engagement in vaping cessation among adolescents, focusing on disparities in knowledge, attitu...

Severe Sydney funnel-web spider envenomation in a toddler: a case report

Introduction Sydney funnel-web spider (Atrax robustus) envenomation produces overlapping catecholaminergic and cholinergic toxidromes that can progress rapidly to life-threatening cardiorespiratory compromise. Airway management in this setting carries unique pharmacodynamic chall...

Economic evaluations of remifentanil versus fentanyl for analgo‐sedation in mechanically ventilated adult ICU patients: a systematic review

Abstract The use of opioid and sedative infusions to relieve pain and anxiety is common among patients receiving invasive mechanical ventilation (IMV) in the intensive care unit (ICU). Although remifentanil‐based sedation is feasible, evidence regarding its economic impact remain...

A cost-effectiveness analysis of selective decontamination of the digestive tract in mechanically ventilated patients in the intensive care unit

Objective To evaluate the 24-months cost-effectiveness of selective decontamination of the digestive tract (SDD) versus standard care in mechanically ventilated Intensive Care Unit (ICU) patients. Design Within‑trial cost‑effectiveness analysis using linked administrative healthc...

Ultrasound Archiving in the Emergency Department: Implementation, Governance and 4‐Year Outcomes at an Australian Tertiary Emergency Department

OBJECTIVE: Image archiving is one of the least developed aspects of emergency department ultrasound (ED-US) in Australasia, despite its recognised role in governance, education, quality assurance (QA) and medicolegal protection. A middleware-based ED-US image workflow solution wa...

The association between documented right ventricular dysfunction and in-hospital mortality in mechanically ventilated critically ill patients receiving a noradrenaline infusion: A retrospective observational cohort study

Objective To determine the documentation of right ventricular dysfunction (RVD) in mechanically ventilated patients receiving a noradrenaline infusion, and to assess the association with in-hospital mortality, length of stay (LOS) and treatment intensity. Design and setting This...

A serum protein–to–bilirubin ratio predicts immune-mediated hepatotoxicity in lung cancer patients treated with immune-checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) have transformed outcomes for patients with advanced non-small cell lung cancer (NSCLC) but are associated with immune-related adverse events, including hepatotoxicity. Immune-mediated liver injury can necessitate treatment interruption and imm...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Prenatal Genomics for Sonographers: Enhancing Confidence, Communication, and Clinical Care

ABSTRACT Genomic medicine is advancing rapidly, bringing significant changes to prenatal care and expanding the role of health professionals. As clinicians responsible for performing prenatal ultrasounds which may detect fetal anomalies and ultimately lead to genetic diagnoses, s...

Intrapartum Febrile Morbidity and Maternal Birth Trauma After Vaginal Delivery: A Parity-Stratified Retrospective Cohort Study

Objective: We aimed to evaluate the association between intrapartum febrile morbidity and maternal birth trauma among women undergoing vaginal delivery, with stratification by parity. Methods: This retrospective cohort study included women with singleton, cephalic, vaginal delive...

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive...

Predictive pre-resection robotic ligament balancing in total knee arthroplasty is accurate across surgeons and patient factors

New robotic total knee arthroplasty (TKA) technology enables force-controlled pre-resection joint gap assessment. Its accuracy across surgeons and patient factors remains unknown. This study evaluated how accurately this technology achieved planned joint gaps and whether accuracy...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Outcomes following dialysis and transplantation in amyloidosis: ANZDATA analysis

Abstract Background The kidneys are frequently affected by systemic amyloidosis. Despite this, contemporary survival outcomes for patients reaching kidney failure due to amyloidosis remain poorly defined relative to other causes of kidney failure. This study aims to characterise...