Nemours Children's Health System

Enoxaparin dose assessment in paediatric cardiology patients

Abstract Background: Enoxaparin is a commonly utilized anticoagulant, particularly in infants and children. Recent literature has highlighted the need to initiate enoxaparin at higher doses, especially at younger ages, due to differences in pharmacokinetics and pharmacodynamics....

Association of Early Primary Care Follow-Up With Acute Care Use After ICU Discharge

OBJECTIVE: To determine if early primary care follow-up after pediatric intensive care unit (PICU) hospitalization is associated with reduced acute care use. METHODS: Using claims data from publicly and privately insured children, we identified a cohort of PICU hospitalizations f...

Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals

ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utili...

Behavioral Interventions in Pediatric Type 1 Diabetes Management: An Updated Meta-Analysis

CONTEXT: The last meta-analysis of behavioral interventions regarding pediatric type 1 diabetes (T1D) management was conducted over a decade ago. OBJECTIVE: This meta-analysis aimed to (1) provide an updated review of adherence-promoting behavioral interventions and their effect...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Leveraging dog models to uncover human cancer insights

Background: Comparative genomics can reveal insights into human disease that cannot be identified from human data alone. Dogs are particularly useful for comparative genomics studies as they share human diet and environment, and, from a genomics perspective, dogs are closely rela...

Comprehensive characterization and translational implications of the GalnsR384C mouse model of Mucopolysaccharidosis IVA

Abstract Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to progressive accumulation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S) and resulting in systemic skeletal...

Delayed methotrexate toxicity after initial clearance in a critically ill patient with severe fluid overload

Methotrexate (MTX) toxicity is a life-threatening complication in oncology patients. We report a 19-year-old male with newly diagnosed Burkitt lymphoma who received high-dose methotrexate as part of induction chemotherapy and initially met protocol-defined serum clearance criteri...