Nebraska Medical Center

Human Metapneumovirus Diagnosis, Pathogenesis, and Therapeutics

Human metapneumovirus (hMPV) is a globally prevalent respiratory pathogen that causes acute respiratory infections across all age groups, with the greatest disease burden in young children, older adults, and immunocompromised individuals. Clinical manifestations range from mild u...

cAMP signaling promotes acute lysosome biogenesis through TFEB nuclear import-export dynamics.

Cyclic adenosine monophosphate (cAMP) signaling is a major stimulus for lipid and glucose catabolism, yet catabolic processes like these can also coordinate with lysosome-dependent degradation. However, the impact of cAMP signaling on lysosomal dynamics remains unclear. Transcrip...

The Nuances of Cost-Related Medication Non-Adherence in Patients Receiving Immunosuppression Compared to Patients with Chronic Disease: A Cross-Sectional Study

Background: Medication adherence rates across diseases that require immunosuppression, including autoimmune diseases, are low. While cost barriers affect medication adherence, it is unknown whether adherence rates related to cost barriers differ between medically immunosuppressed...

Population pharmacokinetics modeling of albendazole and its active metabolite, albendazole sulfoxide in mass drug administration against lymphatic filariasis

ABSTRACT Albendazole (ALB), a benzimidazole antiparasitic, is widely used in mass drug administration (MDA) campaigns against lymphatic filariasis (LF). It is rapidly metabolized to its active form, albendazole sulfoxide (ALB-OX), which exhibits considerable interindividual varia...

Claudin-2 protects from enteropathogenic E. coli-infection and colitis by promoting crypt fetalization via β1-integrin/FAK/YAP signaling

Abstract Citrobacter rodentium ( Cra ) infection, a murine model of enteropathogenic Escherichia coli (EPEC) infection, induces crypt proliferation that potentially promotes mucosal healing and pathogen clearance, yet the underlying molecular mechanisms remain poorly understood....

Network analysis reveals that total hip arthroplasty restores shared segmental motion before segmental differentiation

Unilateral hip osteoarthritis (HOA) reshapes whole-body movement, and total hip arthroplasty (THA) restores function only partially—but conventional kinematic analyses fall short of characterizing how the body’s distributed coordination reorganizes. Network analyses of inter-segm...

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

Neural Mechanisms of Heart-Lung Crosstalk in Chronic Heart Failure

BACKGROUND: The cardiac sympathetic afferent reflex and pulmonary spinal afferent reflex amplify sympathetic activity and may contribute to chronic heart failure. We hypothesized that cardiac injury triggers a cardiac nerve-mediated cytokine uptake cascade that propagates neural...

A qualitative case study on HIV treatment and prevention perceptions within a substance use treatment facility

People with substance use disorders (SUD) are disproportionately impacted by HIV due to overlapping structural, behavioral, and access disparities. Despite advances in antiretroviral therapy and pre-exposure prophylaxis, barriers to HIV testing, prevention, and engagement in care...

Comparison of Caregiver and Child Mand Modality Preferences Using Sequential Extinction During Functional Communication Training

ABSTRACT Functional communication training has been found to be an effective treatment for individuals with developmental disabilities who exhibit challenging behavior. Despite strong empirical support, variables such as preference for the functional communication response modali...

Pharmacokinetics and Toxicity Assessment of Artesunate and Its Metabolite, Dihydroartemisinin, in NOD Scid Gamma Mice

Artesunate (ART) is an FDA-approved antimalarial drug and is currently being repurposed for various solid tumor treatments. However, there are no safety or pharmacokinetic (PK) studies in mice exploring its potential application in murine brain tumor models. This study aims to de...

Financial Impact of a Long-Acting Injectable Cabotegravir/Rilpivirine Program: A Real-World Experience

Abstract Background Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) is an effective HIV treatment, but barriers, such as financial considerations limit implementation. Understanding the real-world financial impact is essential for program sustainability and equita...

Evaluating Variations of Feeder Attention in Mitigating the Side Effects of Escape Extinction

Research has shown that removing bites is the primary motivator for children with feeding difficulties to engage in inappropriate mealtime behavior (IMB) and escape extinction (EE) is the most well-established treatment component. Escape extinction may result in temporary but neg...

Turns and downturns in aging drivers

As cognitive decline progresses, older adults may self-regulate their driving. Avoidance of left turns across traffic is observable in naturalistic driving data but rarely self-reported. We studied 106 older adults using baseline and one-year follow-up neuropsychological assessme...