Nawi Graz

Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations

Reductive amination catalysed by imine reductases and reductive aminases has emerged as a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, we combine large-scale, iterative...

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...

Content and composition of inorganic X-ray amorphous materials in temperate climate soils determined by the Rietveld method

Inorganic X-ray amorphous materials (iXAMs) are reactive soil components, including nanocrystalline minerals and mineraloids, often overlooked by mineralogical analyses. We evaluated their abundance and composition in temperate climate soils (Cambisol, Podzol, Chernozem, and Stag...

Scale-Up of Mechanochemical Amidation in AgitatorBead Mills: From Laboratory to Commercial Scale

Abstract Bead mills are widely used in industry for particle size reduction across diverse applications; however, their use as reactors for mechanochemical synthesis has largely remained limited to laboratory studies, with no prior demonstration at a manufacturing-relevant scale....

Paleozoic Tectonic Transition from Arc–Continent Collision to Post-Orogenic Extension in the East Kunlun Orogen: Constraints from Metamorphic Events

Abstract The tectonic evolution of the trench–arc–back-–arc basin system—encompassing back-arc spreading, subduction, basin closure, and the subsequent transition from arc–continent collision to post-collisional extension—represents a fundamental process in the evolution of the P...