Navarrabiomed

Impact of the 2023 ACR/EULAR classification criteria on thrombotic antiphospholipid syndrome: reclassification patterns and long-term outcomes in a 419-patient cohort

The 2023 ACR/EULAR classification criteria for antiphospholipid syndrome (APS) were developed to improve specificity and to define more homogeneous research populations. However, their performance in real-world cohorts of thrombotic APS with long-term hard outcomes remains insuff...

Scaling of an evidence-based intervention program in older people with diabetes and frailty in Latin America. Diabfrail-Latam clinical trial protocol

Objectives Diabfrail-Latam is a project funded by the Horizon 2020 program of the European Commission (EC) and the Global Alliance for Chronic Diseases (GACD). The main objective of this protocol is to describe the clinical validation of a multimodal intervention aimed at older p...

Approach to sarcopenia in older adults: a systematic review of dietary and exercise interventions in the primary care setting

Abstract Background/objectives Population aging presents challenges for society and healthcare, notably in preventing sarcopenia, a condition that impairs older adults’ quality of life and functionality. This article reviews the current literature on dietary and exercise interven...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Host-Derived Proteomic Profiling of Human and Canine Mammary Tumor Xenografts Identifies Enrichment of Lipid Metabolism-Related Pathways

Abstract Breast cancer is the most frequently diagnosed cancer in women worldwide and one of the most common malignancies in dogs. Notable clinical, hormonal and molecular similarities between both species suggest that dogs may serve as a valuable comparative oncology model. Alte...

Are exercise benefits in older adults clinically meaningful?: An ancillary and follow-up analysis of a multicenter randomized controlled trial

Physical exercise is beneficial for older adults, but little is known about inter-individual response variability or whether its effects reach clinical significance. We analyzed individual clinically meaningful responses to exercise in older adults. This is an ancillary analysis...