National University of San Luis

Synthon-Based Crystal Engineering of Mebendazolium Tosylates: Solid-Form Design, Structure−Property Relationships, and Enhanced Solubility from Experimental and DFT Studies

Abstract Salt formation is a well-established crystal engineering strategy to modulate the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients. In the case of mebendazole (MBZ), a broad-spectrum anthelmintic, this approach has been successfully emp...

Soil microbial responses to long-term agricultural practices under no-till: Insights from depth-resolved sampling of shallow soil layers

Abstract Fungal and bacterial communities were characterized at three soil depths (0–3.5 cm, 3.5–7.5 cm, and 7.5–15 cm) in a 15-year no-till field experiment involving diversified crop rotations with two levels of nitrogen fertilization and soybean monoculture. We hypothesized th...

Genome skimming reveals a multipartite mitochondrial genome in the parasitic nematode Dioctophyme renale

Abstract Background Dioctophyme renale , known as the “giant kidney worm,” is a parasitic nematode of significant medical and biological importance due to its large size and complex interactions with various mammals, including humans, causing dioctophymiasis. Despite its importan...