National University of Rosario

Functional export of NDM-7 to outer membrane vesicles in Klebsiella pneumoniae compromises imipenem and cefiderocol activity

ABSTRACT The carbapenemases KPC and NDM are the most widespread determinants of carbapenem resistance in Klebsiella pneumoniae . Whereas KPC is a soluble periplasmic serine-β-lactamase, NDM is a membrane-anchored metallo-β-lactamase (MBL), a feature that promotes its incorporatio...

Adaptive landscape of the metallo-β-lactamase NDM-1 to emerging β-lactam-based therapies

ABSTRACT The New Delhi metallo-β-lactamase (NDM) is a major determinant of carbapenem resistance. This has prompted the development of novel therapeutic strategies to treat NDM producers. Since these therapies impose new selective pressures, their clinical deployment may favor ND...

Control of organ size by TAS3A

Summary Plant organ size depends on the coordination of cell proliferation and expansion, a process regulated by numerous factors, including transcription factors and small RNAs. However, how different small‐RNA pathways are integrated with growth‐regulating transcriptional netwo...

Beyond Catalysis: Physiology, Cellular Biology And Therapeutic Strategies for Metallo-β-Lactamase-Producing Pathogens

Abstract Metallo-β-lactamases (MBLs) are zinc-dependent β-lactamases that threaten the clinical utility of carbapenems and other last-line β-lactams in Gram-negative pathogens. Their impact cannot be explained solely based on their catalytic efficiency. Clinically relevant MBLs d...

Cycling Versus Swapping After First-Line TNF Inhibitor Failure in Psoriatic Arthritis: Real-World Insights From the Argentine RECCAPSO Registry

Objectives: Cycling within the same mechanism of action (MoA) or swapping to a different MoA are 2 strategies after failure of advanced therapy in psoriatic arthritis (PsA). We described the frequency, clinical characteristics, and treatment trajectory of cycling versus swapping...

Effects of rhythmic auditory stimulation on functional mobility and gait in individuals with Parkinson’s disease in a community environment

Objective To examine the effects of rhythmic auditory stimulation (RAS) on functional mobility and gait speed in Parkinson’s disease (PD) across indoor and supervised outdoor environments.Methods Of 52 individuals screened, 27 were enrolled in a repeated-measures design. Particip...

BDF6 Deficiency Severely Compromises Intracellular Amastigote Development and Infectivity of Trypanosoma cruzi

Abstract Trypanosoma cruzi, the causative agent of Chagas disease, relies on complex gene regulatory mechanisms to adapt to its diverse host environments. In recent years, it has been established that epigenetics plays an essential role in these mechanisms via the regulation of c...

Subnational Heterogeneity in RSV Seasonality in Tropical Colombia, 2022–2024

Abstract Background RSV transmission in tropical settings is often assumed to occur year-round, and preventive strategies are frequently recommended accordingly. However, sub-national variation in epidemic timing remains incompletely characterized. Granular local surveillance dat...