National University Hospital

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

P1.042. Utility of a Fenestrated Surgical Drain for the Prevention and Treatment of Esophageal Leak

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Esophageal transmural defects are associated with high morbidity and mortality. Sponge-based endoscopic vacuum therapy (EVT) is effective but costly and requires fr...

Proteomic Profiling of Human Sweat Reveals Molecular Adaptations to Heat Acclimatization Induced by Isothermic Conditioning

Introduction: Prolonged physical exertion in hot and/or humid environments can induce physiological strain and increase the risk of heat exhaustion or exertional heat stroke (EHS). Heat acclimatization (HA) optimizes an individual’s ability to tolerate heat and is therefore widel...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Incidence and Risk Factors for Progression of Pachychoroid Subtype

Importance The incidence and determinants of progression across the pachychoroid subtype remain incompletely characterized, limiting risk stratification and follow-up strategies. Objective To evaluate progression, diagnostic transitions, and associated risk factors in eyes with p...

Characterisation of liver disease using quantitative MRI: report of the imaging arm of the ELEGANCE study

Evolving disease aetiology and rising prevalence of chronic liver disease are driving an increase in hepatocellular carcinoma (HCC). Non-contrast quantitative MRI (qMRI) has shown promising capability for characterising liver health and risk of liver related outcomes, but has not...

Genomic, transcriptomic, and molecular predictors of response to neoadjuvant therapy in locally advanced rectal cancer: a narrative review

Total neoadjuvant therapy (TNT) has emerged as a key treatment paradigm for locally advanced rectal cancer, reducing distant metastasis rates and facilitating organ preservation in selected patients. However, treatment response remains heterogeneous, highlighting the need for bio...