National University Hospital

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Perioperative Hospital‐at‐Home Program: A Scoping Review

BACKGROUND: Hospital-at-Home (HaH) is an established model of care for medical patients, particularly following rapid expansion during the COVID-19 pandemic. In contrast, perioperative HaH remains in its early stages, with limited understanding of appropriate care delivery models...

Development and Validation of a Tool to Measure Documented Health Care Encounter Time

Importance Time toxicity, defined as the time patients spend receiving cancer treatment and interacting with health care systems, is an emerging treatment-related burden. Existing studies typically quantify time toxicity using health care contact days, which may inadequately capt...

Small Wonders: How Nanotechnology Is Redefining Shoulder and Elbow Surgery

Objective: Nanotechnology has been increasingly incorporated into shoulder and elbow surgery, from bioinductive collagen scaffolds for rotator cuff repair to nanostructured implant surfaces for arthroplasty and nanoparticle-functionalized sutures for elbow tendon repair. This rev...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

The severity and predictors of abdominal aortic calcification among hemodialysis patients: a cross-sectional study from Palestine

Abstract Abdominal aortic calcification (AAC) is a clinically important marker of systemic vascular disease and cardiovascular risk in patients receiving maintenance hemodialysis. Evidence from Palestine remains limited. This study assessed the prevalence and severity of AAC and...

Lack of Knee Confidence Is Associated With Lower Functional Scores After Anterior Cruciate Ligament Reconstruction at 2‐Year Follow‐Up

Purpose To evaluate how patients rate their knee confidence after anterior cruciate ligament injury, when confidence in their knee returns after anterior cruciate ligament reconstruction (ACLR), and how knee confidence correlates with self‐reported outcomes related to return to s...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Efficacy of a soft robotic exoskeleton for upper-limb rehabilitation in subacute stroke inpatient rehabilitation: a randomised controlled trial

Soft robotic devices may be a useful adjunct for stroke rehabilitation by providing higher intensity training, while allowing comfort and portability compared to rigid exoskeletons. We evaluated the efficacy of a sensor-assisted soft robotic glove (SSR) during inpatient stroke re...

Transition of children with chronic gastrointestinal and liver disease to adult care: A multicentre Asian survey of paediatric gastroenterologists

OBJECTIVES: The rising incidence of chronic gastrointestinal conditions and better survival of children with life-limiting diseases have resulted in the need for continuity of care into adulthood. This study aimed to detail transition practices in paediatric gastroenterology and...

Patient-centered outcomes of double-J ureteral stents: Symptom frequency and satisfaction in a resource-limited healthcare system

Objective: This study aimed to quantify the prevalence and severity of indwelling double-J (DJ) ureteral stent-related symptoms, characterize pain perception, and evaluate patient satisfaction among adult patients in a resource-limited healthcare system, while identifying demogra...

Artificial intelligence–driven decision-making after endoscopic resection for early gastric cancer

Early gastric cancer (EGC) is increasingly managed by endoscopic resection (ER); however, lymph node metastasis (LNM), which occurs in approximately 5%-10% of cases, remains the key determinant for recommending additional gastrectomy. Current guideline-based strategies, including...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Machine Learning-Based First-Trimester Antenatal Risk Prediction for Adverse Maternal and Neonatal Outcomes: Multicenter Model Development Study.

Background: Maternal outcomes remain inequitable worldwide. Severe morbidity persists, and current risk assessment tools are largely arbitrary, focusing on biomedical factors while overlooking social determinants of health. There is a need for data-driven AI models to improve ear...

Effects of mandibular advancement device versus continuous positive airway pressure on cardiac remodeling in obstructive sleep apnea: a randomized CMR substudy

Obstructive sleep apnea (OSA) is associated with adverse cardiac remodeling, including diffuse myocardial fibrosis. Continuous positive airway pressure (CPAP) is the standard treatment for OSA, while mandibular advancement devices (MAD) may represent an alternative. However, thei...

The impact and evolution of environmental/occupational, behavioural, and metabolic risk factors on CVD burdens in the Asia–Pacific region from 1990 to 2023: a secondary analysis of the Global Burden of Disease Study 2023

Background Understanding epidemiological trends of the cardiovascular risk factors is integral in designing effective countermeasures in tackling cardiovascular diseases (CVD) in the Asia–Pacific. The study aims to examine the cardiovascular risk factor burden in the Asia–Pacific...

Evaluation of a novel multi-purpose ophthalmic block simulator amongst ophthalmology trainees

Abstract Purpose Training to perform ophthalmic blocks is often done on actual patients by trial and error. Higher complication rates and poor patient experience occur from a suboptimal block. We assess the efficacy of a novel ophthalmic block simulator via a pilot study. Design:...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

P1.042. Utility of a Fenestrated Surgical Drain for the Prevention and Treatment of Esophageal Leak

Abstract Topic Benign Disease: Iatrogenic Esophageal Disease, Perforation and Postsurgical Complications Background Esophageal transmural defects are associated with high morbidity and mortality. Sponge-based endoscopic vacuum therapy (EVT) is effective but costly and requires fr...

Proteomic Profiling of Human Sweat Reveals Molecular Adaptations to Heat Acclimatization Induced by Isothermic Conditioning

Introduction: Prolonged physical exertion in hot and/or humid environments can induce physiological strain and increase the risk of heat exhaustion or exertional heat stroke (EHS). Heat acclimatization (HA) optimizes an individual’s ability to tolerate heat and is therefore widel...