National University College

Comparison of diestrus duration and temporal gene expression patterns in vaginal smear samples from pseudopregnant rats induced by sonic vibration or mating with vasectomized males

BACKGROUND: Induction of pseudopregnancy is a prerequisite for successful embryo transfer in rats. Conventionally, pseudopregnancy is induced by mating females with vasectomized males. Although effective, this method requires surgical preparation and maintenance of sterile males...

Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis

Postmenopausal osteoporosis (PMOP) arises from a bone remodeling imbalance in which osteoclast-mediated resorption exceeds osteoblast-driven formation. However, current therapies primarily target osteoclasts without restoring osteoblast function, underscoring the need for mechani...