National Taipei University of Nursing and Health Science

Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta‐Analysis

BACKGROUND: Hypertension is a significant public health issue affecting over a billion adults worldwide with adherence to antihypertensives being crucial for achieving sustained blood pressure control and reducing cardiovascular morbidity and mortality. To extend previous evidenc...

Multi-Locus Molecular Findings in Pediatric-Onset Inherited Metabolic Disorders: An Eight-Year Series of Outsourced Genomic Testing in Taiwan

Background/Objectives: Outsourced genomic testing can identify additional findings in patients with inherited metabolic disorders (IEMs), including lysosomal storage diseases. We examined these findings in a selected Taiwanese series. Methods: We retrospectively reviewed 13 patie...

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework

Inherited mitochondrial cardiomyopathies arise from pathogenic variants affecting oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin remodeling, protein import, cofactor metabolism, and mitochondrial dynamics or proteostasis. These disorders may be cardiac-pred...

A mixed-methods study of a combined modeling video and OSCE-based teaching intervention for prenatal nutrition counseling self-efficacy among nursing–midwifery students

With this study, we examined changes in prenatal nutrition counseling self-efficacy among nursing–midwifery students through a modeling video and Objective Structured Clinical Examination-based intervention during prenatal medical visits. A sequential explanatory mixed-methods de...

Total Syntheses and Structural Reassignment of Ugonin T and Neougonin B: Anti-inflammatory Flavonoids Related to Helminthostachys zeylanica

Abstract This study reports the first total syntheses of the naturally occurring flavonoids ugonin C (1), ugonin F (2), and, based on the originally proposed structures, compounds 3 and 4 (corresponding to the structures first assigned to ugonin T and neougonin B, respectively),...

Association Between Unenhanced CT Features and Perioperative Outcomes in Bronchogenic Cyst Resection

Background: Reliable predictors of perioperative risk beyond symptomatology in bronchogenic cyst (BC) resection are lacking. We aimed to compare perioperative outcomes across different imaging features to identify perioperative risk factors. Methods: We conducted a retrospective...

Long-Term Air Pollutant Exposure and the Risk of Cardiovascular- and Cancer-Related Mortality: A Prospective Cohort Study in Taiwan

Air pollution exposure can cause vascular dysfunction and induce mutagenesis; however, its effects on cardiovascular disease (CVD)– and cancer-related mortality remain unclear. This prospective cohort study examined the impact of long-term exposure to multiple air pollutants on t...

Rebalancing mitochondrial dynamics restores succinate dehydrogenase activity and reduces succinate release in hepatocellular carcinoma

BACKGROUND: Dysregulated mitochondrial dynamics in cancer cells perturbs mitochondrial function and metabolism and promotes cancer progression. Its impacts on the electron transport chain, oxidative phosphorylation, redox balance, and glycolysis are well recognized. However, its...

Early Antiviral Therapy in Pediatric Outpatients and Risk of Influenza-Related Hospitalization

OBJECTIVES: Evidence on the effectiveness of antiviral therapy in preventing influenza-related severe illness and hospitalization among children remains limited. We hypothesized that early administration of antiviral therapy within 48 hours of symptom onset would significantly re...

Development and evaluation of a hybrid clinical and deep-learning ECG model for predicting in-hospital cardiac arrest

In-hospital cardiac arrest (IHCA) is often unexpected, and existing early warning scores based mainly on vital signs have limited predictive performance. We developed and internally evaluated clinical, deep-learning electrocardiographic, and hybrid models for IHCA prediction in a...

Diabetes mellitus and risk of injury requiring medical care: a nationwide population-based matched cohort study in Taiwan

Abstract Background Diabetes mellitus (DM) is associated with multiple microvascular and macrovascular complications; however, its association with clinically significant injury requiring medical care remains incompletely understood. This study aimed to investigate the associatio...