National Science and Technology Development Agency

Gold Nanoparticle Shape and Protein Corona Effects on Radiosensitization in Neuroblastoma Cells

Abstract Gold nanoparticle (GNP) radiosensitization is influenced by particle shape and the protein corona acquired in biological environments. We investigated how GNP shape and a preformed human plasma protein corona affect the radiation response of SH-SY5Y neuroblastoma cells e...

Eggshell‐Derived Surface‐Modified Hydroxyapatite as a Sustainable Filler for Styrene–Butadiene Rubber Composites

ABSTRACT This study demonstrates the conversion of eggshell waste into hydroxyapatite (HAP) as a sustainable bio‐derived reinforcing filler for styrene–butadiene rubber (SBR) composites. HAP was synthesized from eggshell‐derived calcium oxide and surface‐modified by ball milling...

Green synthesis of silver-chitosan nanocomposites for colorimetric detection of malathion in aqueous systems

This study presents a green hydrothermal synthesis of silver-chitosan nanoparticles (AgCs NPs) as a bio-based colorimetric platform for malathion (MLT) detection. Chitosan (Cs) served as both a reducing and stabilizing agent, enabling the formation of spherical AgNPs, as characte...

Ru-Promoted Ni/ZIF-8 Catalysts for C–C Coupling in the Upgrading of Acetone–Butanol–Ethanol Mixtures

Catalytic upgrading of acetone–butanol–ethanol (ABE) mixtures provides a route to higher-value oxygenates for chemicals and fuel precursors. Here, Ni-, Ru-, and Ni–Ru-loaded ZIF-8 catalysts were prepared and evaluated for ABE upgrading, with particular emphasis on C7 oxygenate fo...

Bipyridine-Functionalized Covalent Organic Polymer for Highly Sensitive Turn-On Fluorescent Detection of Zn2+ in Pure Water

Abstract A bipyridine-functionalized covalent organic polymer (Bpy-COP) was synthesized as a fluorescent sensor for Zn2+ detection in pure water. Structural characterization confirmed the formation of an imine-linked amorphous polymer incorporating accessible bipyridine coordinat...

Direct upcycling of unrecyclable household waste into biodegradable high‑performance biocomposites

Abstract In the UK, post-consumer waste is sent to materials recovery facilities (MRFs) to separate the metals, plastics, paper and cardboard for subsequent recycling. However, a significant portion of materials sent to MRFs are rejected. Here, we demonstrate a pathway that direc...

Ogataea Yeast Platform for Recombinant Porcine Interferon-Alpha 1 Production: Toward Alternative Biotherapeutics for Swine Health Management

Infectious diseases in swine demand affordable, broad-spectrum antiviral strategies, such as recombinant interferons (IFNs). However, commercial yeast expression platforms often present financial barriers through licensing royalties. To provide a cost-effective regional alternati...

Electrochemical Dual-Sensing Platform for HLA-B*13:01 Detection to Prevent Severe Cutaneous Adverse Reactions (SCARs) Induced by Dapsone and Cotrimoxazole

Abstract The HLA-B*13:01 allele is a critical biomarker for dapsone- and cotrimoxazole-induced severe cutaneous adverse reactions (SCARs). Overcoming the limitations of centralized laboratory screening, we developed a portable electrochemical dual-sensing platform (EDP) for the s...

Rare WDR19 Variants in Patients With Dental and Retinal Anomalies

Genetic variants in WDR19 cause ciliopathies with craniofacial and ectodermal features, including dental and retinal anomalies. This study characterized the clinical and molecular features of patients with isolated dental anomalies harboring WDR19 variants. Clinical and radiograp...

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...

Sustainable Valorization of Palm Fatty Acid Distillate into Amide-based Corrosion Inhibitors for Carbon Steel Protection in CO2-Saline Environments

Abstract A PFAD-based amide corrosion inhibitor was synthesized from palm fatty acid distillate (PFAD), an abundant palm oil refining byproduct in Thailand, and diethylenetriamine (DETA) to enhance PFAD value and reduce inhibitor production costs. The synthesized amide was confir...

Metabolic and Inflammatory Risk Stratification in Resected Cholangiocarcinoma: A Retrospective Exploratory Analysis

Background: Cholangiocarcinoma (CCA) frequently recurs after curative-intent resection. Metabolic alterations and systemic inflammation may contribute to aggressive disease, but their combined prognostic relevance remains unclear. Methods: We retrospectively reanalyzed 88 patient...

Gamma irradiation-induced metabolic reprogramming as a determinant of radiation tolerance in thai rice germplasm for space agriculture

Abstract Radiation beyond Earth’s atmosphere poses a major challenge for space agriculture by affecting seed viability and plant establishment. As a controllable terrestrial analogue of cosmic radiation, gamma (γ) irradiation provides a practical model for evaluating crop resilie...

Humidity-Enhanced Effects of Sputtered Au Nanoparticles on the Ethanol Sensing Performance of Thermally Evaporated ZnO Nanowires

Abstract Mitigating the adverse effects of humidity on the sensing performance of one-dimensional (1D) metal oxide semiconductors has been a key challenge in gas sensor development. This study investigated the humidity-enhanced effect of gold (Au) nanoparticles on the ethanol res...

3D-Printed Poly(ε-Caprolactone)/CaCO3 Biocomposite Meshes for Bone Tissue Engineering: EnhancedMechanicalStrength and Cytocompatibility

Abstract Poly(ε-caprolactone) (PCL) is a biodegradable and biocompatible polyester widely used in biomedical scaffolds. However, its relatively low mechanical strength and limited cell adhesion properties remain major challenges for bone tissue engineering applications. This stud...

Mechanical-press torrefaction of Napier grass for bio-coke production: effects of temperature and pressure on densification, fuel properties, and CO2 gasification behavior

This study investigated a mechanical-press torrefaction-assisted carbonization route for producing Napier grass-derived bio-coke. Napier grass was first torrefied under mechanical pressure at 280–340 °C and 20–70 MPa, followed by carbonization at 1000 °C. The effects of torrefact...

Phenotypic and Genomic Analysis of Swine-Derived Bacillus subtilis 1BP1Co1 as a Functional Probiotic Candidate to Mitigate Escherichia coli-Associated Diarrhea

Post-weaning diarrhea caused by pathogenic Escherichia coli is a significant economic challenge in global swine production. Rising antimicrobial resistance linked to traditional antibiotics necessitates safe, sustainable alternatives. This study isolated and characterized host-as...