National Sagamihara Hospital

Prion-like transmission of human tau strains in the mouse brain

Abstract Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding 1 . Distinct conformations of amyloid filaments may provide the physical basis for the strains th...

Comparison between Janus kinase inhibitor monotherapy and combination therapy with methotrexate in patients with rheumatoid arthritis: insight from the National Database of Rheumatic Diseases in Japan (NinJa) registry

Abstract Background: Janus kinase inhibitors (JAKi) are effective for rheumatoid arthritis (RA) and can be used as monotherapy; however, the clinical benefit of concomitant methotrexate (MTX) and the optimal MTX dose in JAKi-treated patients remain unclear in real-world settings....

Long‐term outcome after resection and reconstruction using vaginourethroplasty for distal urethral leiomyosarcoma in a female dog

OBJECTIVE: To describe vaginourethroplasty-based resection and reconstruction of distal urethral leiomyosarcoma in a female dog and report long-term outcomes. STUDY DESIGN: Case report. ANIMALS: One 10-year-old spayed female mixed-breed dog. METHODS: Retrograde urethrovaginograph...

Algorithm for classifying the underlying pathologies in postpartum hemorrhage using bleeding rate, fibrinogen, and fibrin/fibrinogen degradation products: a case series study

Abstract Background Understanding patients’ underlying pathologies is essential for appropriate treatment during postpartum hemorrhage (PPH) management. The objective of this study is to develop an algorithm that quantitatively classifies the underlying pathologies in PPH using c...